3-(4-amino-7-(3-hydroxypropyl)-5-p-tolyl-7H-pyrrolo[2,3-d]pyrimidin-6-yl)-2-cyano-N-isopropylpropanamide

Base Information

Chemical Name:3-(4-amino-7-(3-hydroxypropyl)-5-p-tolyl-7H-pyrrolo[2,3-d]pyrimidin-6-yl)-2-cyano-N-isopropylpropanamide
CAS No.:1307896-39-4
Molecular Formula:C₂₃H₂₈N₆O₂
Molecular Weight:420.514
Hs Code.:

Synonyms:3-(4-amino-7-(3-hydroxypropyl)-5-p-tolyl-7H-pyrrolo[2,3-d]pyrimidin-6-yl)-2-cyano-N-isopropylpropanamide

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Chemical Property of 3-(4-amino-7-(3-hydroxypropyl)-5-p-tolyl-7H-pyrrolo[2,3-d]pyrimidin-6-yl)-2-cyano-N-isopropylpropanamide

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Technology Process of 3-(4-amino-7-(3-hydroxypropyl)-5-p-tolyl-7H-pyrrolo[2,3-d]pyrimidin-6-yl)-2-cyano-N-isopropylpropanamide

There total 10 articles about 3-(4-amino-7-(3-hydroxypropyl)-5-p-tolyl-7H-pyrrolo[2,3-d]pyrimidin-6-yl)-2-cyano-N-isopropylpropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 24.0%

: 1307895-82-4
3-(4-amino-7-(3-hydroxypropyl)-5-p-tolyl-7H-pyrrolo[2,3-d]pyrimidin-6-yl)-2-cyano-N-isopropylacrylamide

: 1307896-39-4
3-(4-amino-7-(3-hydroxypropyl)-5-p-tolyl-7H-pyrrolo[2,3-d]pyrimidin-6-yl)-2-cyano-N-isopropylpropanamide

Guidance literature:: With sodium cyanoborohydride; acetic acid; In methanol; at 20 ℃; for 24h;

Reference yield:

: 52573-74-7
2-cyano-N-isopropylacetamide

: 1307896-39-4
3-(4-amino-7-(3-hydroxypropyl)-5-p-tolyl-7H-pyrrolo[2,3-d]pyrimidin-6-yl)-2-cyano-N-isopropylpropanamide

Guidance literature:: Multi-step reaction with 3 steps

1: piperidine / tetrahydrofuran / 96 h / 20 °C

2: hydrogenchloride / tetrahydrofuran; water / 1.5 h / 20 °C

3: sodium cyanoborohydride; acetic acid / methanol / 24 h / 20 °C

With piperidine; hydrogenchloride; sodium cyanoborohydride; acetic acid; In tetrahydrofuran; methanol; water;

Reference yield:

: 1307896-58-7
N'-(3-cyano-4-p-tolyl-1H-pyrrol-2-yl)formimidamide

: 1307896-39-4
3-(4-amino-7-(3-hydroxypropyl)-5-p-tolyl-7H-pyrrolo[2,3-d]pyrimidin-6-yl)-2-cyano-N-isopropylpropanamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: sodium methylate / methanol / 3 h / Reflux

2.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 - 20 °C

2.2: 4 h

3.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 24 h

4.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / 3 h / Inert atmosphere

5.1: sodium periodate; osmium(VIII) oxide / tetrahydrofuran; water; tert-butyl alcohol / 2 h / 20 °C / Inert atmosphere

6.1: piperidine / tetrahydrofuran / 96 h / 20 °C

7.1: hydrogenchloride / tetrahydrofuran; water / 1.5 h / 20 °C

8.1: sodium cyanoborohydride; acetic acid / methanol / 24 h / 20 °C

With piperidine; hydrogenchloride; sodium periodate; N-Bromosuccinimide; osmium(VIII) oxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium methylate; sodium hydride; sodium cyanoborohydride; acetic acid; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; toluene; tert-butyl alcohol;