(4-((6-(indolin-5-yl)imidazo[1,2-a]pyrazin-8-yl)amino)phenyl)(morpholino)methanone

Base Information

Chemical Name:(4-((6-(indolin-5-yl)imidazo[1,2-a]pyrazin-8-yl)amino)phenyl)(morpholino)methanone
CAS No.:1622173-57-2
Molecular Formula:C₂₅H₂₄N₆O₂
Molecular Weight:440.505
Hs Code.:

Synonyms:(4-((6-(indolin-5-yl)imidazo[1,2-a]pyrazin-8-yl)amino)phenyl)(morpholino)methanone

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Chemical Property of (4-((6-(indolin-5-yl)imidazo[1,2-a]pyrazin-8-yl)amino)phenyl)(morpholino)methanone

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Technology Process of (4-((6-(indolin-5-yl)imidazo[1,2-a]pyrazin-8-yl)amino)phenyl)(morpholino)methanone

There total 5 articles about (4-((6-(indolin-5-yl)imidazo[1,2-a]pyrazin-8-yl)amino)phenyl)(morpholino)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 886854-84-8
[4-(6-bromo-imidazo[1,2-a]pyrazin-8-ylamino)-phenyl]-morpholin-4-yl-methanone

: 1062174-44-0
5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)indoline

: 1622173-57-2
(4-((6-(indolin-5-yl)imidazo[1,2-a]pyrazin-8-yl)amino)phenyl)(morpholino)methanone

Guidance literature:: With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium carbonate; In 1,4-dioxane; at 100 ℃; for 12h;

Reference yield:

: 5397-76-2
1-morpholin-4-yl-1-(4-nitro-phenyl)-methanone

: 1622173-57-2
(4-((6-(indolin-5-yl)imidazo[1,2-a]pyrazin-8-yl)amino)phenyl)(morpholino)methanone

Guidance literature:: Multi-step reaction with 3 steps

1: palladium 10% on activated carbon; hydrogen / methanol / 4 h / 20 °C

2: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 h / 110 °C

3: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium carbonate / 1,4-dioxane / 12 h / 100 °C

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium 10% on activated carbon; hydrogen; potassium carbonate; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; methanol; N,N-dimethyl-formamide;

Reference yield:

: 62-23-7
4-nitro-benzoic acid

: 1622173-57-2
(4-((6-(indolin-5-yl)imidazo[1,2-a]pyrazin-8-yl)amino)phenyl)(morpholino)methanone

Guidance literature:: Multi-step reaction with 4 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 16 h / 20 °C / Inert atmosphere

2: palladium 10% on activated carbon; hydrogen / methanol / 4 h / 20 °C

3: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 h / 110 °C

4: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium carbonate / 1,4-dioxane / 12 h / 100 °C

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium 10% on activated carbon; hydrogen; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; methanol; N,N-dimethyl-formamide;