5-(5-(4-amino-3-isopropoxybenzamido)-6-isopropoxypicolinamido)-6-isopropoxypicolinic acid

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Chemical Name:5-(5-(4-amino-3-isopropoxybenzamido)-6-isopropoxypicolinamido)-6-isopropoxypicolinic acid
CAS No.:1373319-36-8
Molecular Formula:C₂₈H₃₃N₅O₇
Molecular Weight:551.599
Hs Code.:

Synonyms:5-(5-(4-amino-3-isopropoxybenzamido)-6-isopropoxypicolinamido)-6-isopropoxypicolinic acid

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Chemical Property of 5-(5-(4-amino-3-isopropoxybenzamido)-6-isopropoxypicolinamido)-6-isopropoxypicolinic acid

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Technology Process of 5-(5-(4-amino-3-isopropoxybenzamido)-6-isopropoxypicolinamido)-6-isopropoxypicolinic acid

There total 14 articles about 5-(5-(4-amino-3-isopropoxybenzamido)-6-isopropoxypicolinamido)-6-isopropoxypicolinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 1373319-48-2
methyl 5-(5-(4-amino-3-isopropoxybenzamido)-6-isopropoxypicolinamido)-6-isopropoxypicolinate

: 1373319-36-8
5-(5-(4-amino-3-isopropoxybenzamido)-6-isopropoxypicolinamido)-6-isopropoxypicolinic acid

Guidance literature:: With water; sodium hydroxide; In tetrahydrofuran; methanol; at 20 ℃; Inert atmosphere;
DOI:10.1039/c2ob07125h

Reference yield:

: 16013-85-7,136901-10-5
2,6-dicholoro-3-nitropyridine

: 1373319-36-8
5-(5-(4-amino-3-isopropoxybenzamido)-6-isopropoxypicolinamido)-6-isopropoxypicolinic acid

Guidance literature:: Multi-step reaction with 10 steps

1.1: toluene / 0.25 h / 0 °C

1.2: 16.25 h / 0 - 20 °C / Inert atmosphere

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / 16 h / 120 °C / Inert atmosphere

3.1: potassium permanganate / water; acetone / 12 h / 20 °C

4.1: thionyl chloride / 12 h / 0 °C / Reflux; Inert atmosphere

5.1: tin(II) chloride dihdyrate / ethyl acetate / 12 h / 50 °C / Inert atmosphere

6.1: dichlorotriphenylphosphorane / chloroform / Reflux; Inert atmosphere

7.1: tin(II) chloride dihdyrate / ethyl acetate / 12 h / 50 °C / Inert atmosphere

8.1: dichlorotriphenylphosphorane / chloroform / Reflux; Inert atmosphere

9.1: tin(II) chloride dihdyrate / ethyl acetate / 12 h / 50 °C / Inert atmosphere

10.1: water; sodium hydroxide / tetrahydrofuran; methanol / 20 °C / Inert atmosphere

With potassium permanganate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; thionyl chloride; tin(II) chloride dihdyrate; water; sodium hydroxide; dichlorotriphenylphosphorane; In tetrahydrofuran; methanol; chloroform; water; ethyl acetate; acetone; toluene; 2.1: Stille coupling;
DOI:10.1039/c2ob07125h

Reference yield:

: 186413-80-9
2-isopropoxy-3-nitro-6-vinylpyridine

: 1373319-36-8
5-(5-(4-amino-3-isopropoxybenzamido)-6-isopropoxypicolinamido)-6-isopropoxypicolinic acid

Guidance literature:: Multi-step reaction with 6 steps

1: potassium permanganate / water; acetone / 12 h / 20 °C

2: dichlorotriphenylphosphorane / chloroform / Reflux; Inert atmosphere

3: tin(II) chloride dihdyrate / ethyl acetate / 12 h / 50 °C / Inert atmosphere

4: dichlorotriphenylphosphorane / chloroform / Reflux; Inert atmosphere

5: tin(II) chloride dihdyrate / ethyl acetate / 12 h / 50 °C / Inert atmosphere

6: water; sodium hydroxide / tetrahydrofuran; methanol / 20 °C / Inert atmosphere

With potassium permanganate; tin(II) chloride dihdyrate; water; sodium hydroxide; dichlorotriphenylphosphorane; In tetrahydrofuran; methanol; chloroform; water; ethyl acetate; acetone;
DOI:10.1039/c2ob07125h