methyl 5-(5-(4-amino-3-isopropoxybenzamido)-6-isopropoxypicolinamido)-6-isopropoxypicolinate

Base Information

Chemical Name:methyl 5-(5-(4-amino-3-isopropoxybenzamido)-6-isopropoxypicolinamido)-6-isopropoxypicolinate
CAS No.:1373319-48-2
Molecular Formula:C₂₉H₃₅N₅O₇
Molecular Weight:565.626
Hs Code.:

Synonyms:methyl 5-(5-(4-amino-3-isopropoxybenzamido)-6-isopropoxypicolinamido)-6-isopropoxypicolinate

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Chemical Property of methyl 5-(5-(4-amino-3-isopropoxybenzamido)-6-isopropoxypicolinamido)-6-isopropoxypicolinate

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Technology Process of methyl 5-(5-(4-amino-3-isopropoxybenzamido)-6-isopropoxypicolinamido)-6-isopropoxypicolinate

There total 13 articles about methyl 5-(5-(4-amino-3-isopropoxybenzamido)-6-isopropoxypicolinamido)-6-isopropoxypicolinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 1373319-44-8
methyl 6-isopropoxy-5-(6-isopropoxy-5-(3-isopropoxy-4-nitrobenzamido)picolinamido)picolinate

: 1373319-48-2
methyl 5-(5-(4-amino-3-isopropoxybenzamido)-6-isopropoxypicolinamido)-6-isopropoxypicolinate

Guidance literature:: With tin(II) chloride dihdyrate; In ethyl acetate; at 50 ℃; for 12h; Inert atmosphere;
DOI:10.1039/c2ob07125h

Reference yield:

: 16013-85-7,136901-10-5
2,6-dicholoro-3-nitropyridine

: 1373319-48-2
methyl 5-(5-(4-amino-3-isopropoxybenzamido)-6-isopropoxypicolinamido)-6-isopropoxypicolinate

Guidance literature:: Multi-step reaction with 7 steps

1.1: toluene / 0.25 h / 0 °C

1.2: 16.25 h / 0 - 20 °C / Inert atmosphere

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / 16 h / 120 °C / Inert atmosphere

3.1: potassium permanganate / water; acetone / 12 h / 20 °C

4.1: dichlorotriphenylphosphorane / chloroform / Reflux; Inert atmosphere

5.1: tin(II) chloride dihdyrate / ethyl acetate / 12 h / 50 °C / Inert atmosphere

6.1: dichlorotriphenylphosphorane / chloroform / Reflux; Inert atmosphere

7.1: tin(II) chloride dihdyrate / ethyl acetate / 12 h / 50 °C / Inert atmosphere

With potassium permanganate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; tin(II) chloride dihdyrate; dichlorotriphenylphosphorane; In chloroform; water; ethyl acetate; acetone; toluene; 2.1: Stille coupling;
DOI:10.1039/c2ob07125h

Reference yield:

: 186413-80-9
2-isopropoxy-3-nitro-6-vinylpyridine

: 1373319-48-2
methyl 5-(5-(4-amino-3-isopropoxybenzamido)-6-isopropoxypicolinamido)-6-isopropoxypicolinate

Guidance literature:: Multi-step reaction with 5 steps

1: potassium permanganate / water; acetone / 12 h / 20 °C

2: dichlorotriphenylphosphorane / chloroform / Reflux; Inert atmosphere

3: tin(II) chloride dihdyrate / ethyl acetate / 12 h / 50 °C / Inert atmosphere

4: dichlorotriphenylphosphorane / chloroform / Reflux; Inert atmosphere

5: tin(II) chloride dihdyrate / ethyl acetate / 12 h / 50 °C / Inert atmosphere

With potassium permanganate; tin(II) chloride dihdyrate; dichlorotriphenylphosphorane; In chloroform; water; ethyl acetate; acetone;
DOI:10.1039/c2ob07125h