methyl 6-isopropoxy-5-(6-isopropoxy-5-(3-isopropoxy-4-nitrobenzamido)picolinamido)picolinate

Base Information

Chemical Name:methyl 6-isopropoxy-5-(6-isopropoxy-5-(3-isopropoxy-4-nitrobenzamido)picolinamido)picolinate
CAS No.:1373319-44-8
Molecular Formula:C₂₉H₃₃N₅O₉
Molecular Weight:595.609
Hs Code.:

Synonyms:methyl 6-isopropoxy-5-(6-isopropoxy-5-(3-isopropoxy-4-nitrobenzamido)picolinamido)picolinate

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Chemical Property of methyl 6-isopropoxy-5-(6-isopropoxy-5-(3-isopropoxy-4-nitrobenzamido)picolinamido)picolinate

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Technology Process of methyl 6-isopropoxy-5-(6-isopropoxy-5-(3-isopropoxy-4-nitrobenzamido)picolinamido)picolinate

There total 11 articles about methyl 6-isopropoxy-5-(6-isopropoxy-5-(3-isopropoxy-4-nitrobenzamido)picolinamido)picolinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 379261-85-5
3-(isopropyloxy)-4-nitrobenzoic acid

: 475272-72-1
methyl 5-(5-amino-6-isopropoxypicolinamido)-6-isopropoxypicolinate

: 1373319-44-8
methyl 6-isopropoxy-5-(6-isopropoxy-5-(3-isopropoxy-4-nitrobenzamido)picolinamido)picolinate

Guidance literature:: With dichlorotriphenylphosphorane; In chloroform; Reflux; Inert atmosphere;
DOI:10.1039/c2ob07125h

Reference yield:

: 16013-85-7,136901-10-5
2,6-dicholoro-3-nitropyridine

: 1373319-44-8
methyl 6-isopropoxy-5-(6-isopropoxy-5-(3-isopropoxy-4-nitrobenzamido)picolinamido)picolinate

Guidance literature:: Multi-step reaction with 6 steps

1.1: toluene / 0.25 h / 0 °C

1.2: 16.25 h / 0 - 20 °C / Inert atmosphere

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / 16 h / 120 °C / Inert atmosphere

3.1: potassium permanganate / water; acetone / 12 h / 20 °C

4.1: dichlorotriphenylphosphorane / chloroform / Reflux; Inert atmosphere

5.1: tin(II) chloride dihdyrate / ethyl acetate / 12 h / 50 °C / Inert atmosphere

6.1: dichlorotriphenylphosphorane / chloroform / Reflux; Inert atmosphere

With potassium permanganate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; tin(II) chloride dihdyrate; dichlorotriphenylphosphorane; In chloroform; water; ethyl acetate; acetone; toluene; 2.1: Stille coupling;
DOI:10.1039/c2ob07125h

Reference yield:

: 186413-77-4
6-chloro-3-nitro-2-(propan-2-yloxy)pyridine

: 1373319-44-8
methyl 6-isopropoxy-5-(6-isopropoxy-5-(3-isopropoxy-4-nitrobenzamido)picolinamido)picolinate

Guidance literature:: Multi-step reaction with 5 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / 16 h / 120 °C / Inert atmosphere

2: potassium permanganate / water; acetone / 12 h / 20 °C

3: dichlorotriphenylphosphorane / chloroform / Reflux; Inert atmosphere

4: tin(II) chloride dihdyrate / ethyl acetate / 12 h / 50 °C / Inert atmosphere

5: dichlorotriphenylphosphorane / chloroform / Reflux; Inert atmosphere

With potassium permanganate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; tin(II) chloride dihdyrate; dichlorotriphenylphosphorane; In chloroform; water; ethyl acetate; acetone; toluene; 1: Stille coupling;
DOI:10.1039/c2ob07125h