1-Benzyl-3-(trifluoromethyl)pyrrolidine-3-carboxylic acid

Base Information

Chemical Name:1-Benzyl-3-(trifluoromethyl)pyrrolidine-3-carboxylic acid
CAS No.:186203-08-7
Molecular Formula:C13H14 F3 N O2
Molecular Weight:273.255
Hs Code.:2933990090
European Community (EC) Number:888-947-3
DSSTox Substance ID:DTXSID10599238
Mol file:186203-08-7.mol

Synonyms:186203-08-7;1-benzyl-3-(trifluoromethyl)pyrrolidine-3-carboxylic acid;1-BENZYL-3-TRIFLUOROMETHYL-PYRROLIDINE-3-CARBOXYLIC ACID;SCHEMBL8573303;DTXSID10599238;MFCD11848045;AKOS011164253;AS-70173;DB-421453;CS-0216759;EN300-58944;W15283;1-benzyl-3-(trifluoromethyl)pyrrolidine-3-carboxylicacid;1-benzyl-3-trifluoromethylpyrrolidine-3-carboxylic acid;Z884299902

Suppliers and Price of 1-Benzyl-3-(trifluoromethyl)pyrrolidine-3-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Labseeker
1-Benzyl-3-trifluoromethyl-pyrrolidine-3-carboxylicacid 95
5g
$ 1833.00

American Custom Chemicals Corporation
1-BENZYL-3-TRIFLUOROMETHYL-PYRROLIDINE-3-CARBOXYLIC ACID 95.00%
5G
$ 2392.33

American Custom Chemicals Corporation
1-BENZYL-3-TRIFLUOROMETHYL-PYRROLIDINE-3-CARBOXYLIC ACID 95.00%
2.5G
$ 1771.13

American Custom Chemicals Corporation
1-BENZYL-3-TRIFLUOROMETHYL-PYRROLIDINE-3-CARBOXYLIC ACID 95.00%
1G
$ 1143.61

AK Scientific
1-Benzyl-3-(trifluoromethyl)pyrrolidine-3-carboxylicacid
1g
$ 947.00

AK Scientific
1-Benzyl-3-(trifluoromethyl)pyrrolidine-3-carboxylicacid
500mg
$ 760.00

Total 3 raw suppliers

Chemical Property of 1-Benzyl-3-(trifluoromethyl)pyrrolidine-3-carboxylic acid

Chemical Property:

PSA：40.54000
LogP:2.46350
XLogP3:0.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:3
Exact Mass:273.09766318
Heavy Atom Count:19
Complexity:339

Purity/Quality:

98% ^*data from raw suppliers

1-Benzyl-3-trifluoromethyl-pyrrolidine-3-carboxylicacid 95 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CN(CC1(C(=O)O)C(F)(F)F)CC2=CC=CC=C2

Technology Process of 1-Benzyl-3-(trifluoromethyl)pyrrolidine-3-carboxylic acid

There total 1 articles about 1-Benzyl-3-(trifluoromethyl)pyrrolidine-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 381-98-6
trifluoromethyacrylic acid

: 93102-05-7
N-benzyl-N-(methoxymethyl)-N-[(trimethylsilyl)methyl]amine

: 186203-08-7
1-benzyl-3-(trifluoromethyl)pyrrolidine-3-carboxylic acid

Guidance literature:: With trifluoroacetic acid; In dichloromethane;
DOI:10.1016/S0960-894X(98)00514-9

Reference yield:

: 186203-08-7
1-benzyl-3-(trifluoromethyl)pyrrolidine-3-carboxylic acid

: 186203-15-6
(1-benzyl-3-(trifluoromethyl)pyrrolidin-3-yl)methanol

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran;
DOI:10.1016/S0960-894X(98)00514-9

Reference yield:

: 186203-08-7
1-benzyl-3-(trifluoromethyl)pyrrolidine-3-carboxylic acid

: C-(1-Benzyl-3-trifluoromethyl-pyrrolidin-3-yl)-methylamine

Guidance literature:: Multi-step reaction with 3 steps

1: SOCl₂ / CH₂Cl₂

2: NH₃

3: LiAlH₄ / tetrahydrofuran

With lithium aluminium tetrahydride; thionyl chloride; ammonia; In tetrahydrofuran; dichloromethane;
DOI:10.1016/S0960-894X(98)00514-9