Benzyl 1-(6-(dimethylamino)pyridin-3-yl)piperidin-4-yl(methyl)carbamate

Base Information

Chemical Name:Benzyl 1-(6-(dimethylamino)pyridin-3-yl)piperidin-4-yl(methyl)carbamate
CAS No.:1365156-60-0
Molecular Formula:C₂₁H₂₈N₄O₂
Molecular Weight:368.479
Hs Code.:

Synonyms:Benzyl 1-(6-(dimethylamino)pyridin-3-yl)piperidin-4-yl(methyl)carbamate

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Chemical Property of Benzyl 1-(6-(dimethylamino)pyridin-3-yl)piperidin-4-yl(methyl)carbamate

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Technology Process of Benzyl 1-(6-(dimethylamino)pyridin-3-yl)piperidin-4-yl(methyl)carbamate

There total 4 articles about Benzyl 1-(6-(dimethylamino)pyridin-3-yl)piperidin-4-yl(methyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 26163-07-5
5-bromo-2-dimethylaminopyridine

: 553672-39-2
benzyl N-methyl-N-(4-piperidyl)carbamate

: 1365156-60-0
Benzyl 1-(6-(dimethylamino)pyridin-3-yl)piperidin-4-yl(methyl)carbamate

Guidance literature:: With potassium tert-butylate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In toluene; at 80 ℃; for 16h; Inert atmosphere;

Reference yield:

: 147539-41-1
4-methylamino-piperidine-1-carboxylic acid tert-butyl ester

: 1365156-60-0
Benzyl 1-(6-(dimethylamino)pyridin-3-yl)piperidin-4-yl(methyl)carbamate

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / dichloromethane / 14 h / 20 °C

2: trifluoroacetic acid / dichloromethane / 2 h / 0 - 20 °C

3: potassium tert-butylate / 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene / 16 h / 80 °C / Inert atmosphere

With potassium tert-butylate; potassium carbonate; trifluoroacetic acid; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In dichloromethane; toluene;

Reference yield:

: 847039-05-8
4-(((benzyloxy)carbonyl)(methyl)amino)piperidine-1-carboxylic acid tert-butyl ester

: 1365156-60-0
Benzyl 1-(6-(dimethylamino)pyridin-3-yl)piperidin-4-yl(methyl)carbamate

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid / dichloromethane / 2 h / 0 - 20 °C

2: potassium tert-butylate / 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene / 16 h / 80 °C / Inert atmosphere

With potassium tert-butylate; trifluoroacetic acid; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In dichloromethane; toluene;