(3R,5S,2'R)-3-dimethyl(phenyl)silyl-5-methyl-2-(6'-methylhept-2'-yl)-1-trimethysilyloxylcyclohexene

Base Information

Chemical Name:(3R,5S,2'R)-3-dimethyl(phenyl)silyl-5-methyl-2-(6'-methylhept-2'-yl)-1-trimethysilyloxylcyclohexene
CAS No.:679841-63-5
Molecular Formula:C₂₆H₄₆OSi₂
Molecular Weight:430.822
Hs Code.:

Synonyms:(3R,5S,2'R)-3-dimethyl(phenyl)silyl-5-methyl-2-(6'-methylhept-2'-yl)-1-trimethysilyloxylcyclohexene

Suppliers and Price of (3R,5S,2'R)-3-dimethyl(phenyl)silyl-5-methyl-2-(6'-methylhept-2'-yl)-1-trimethysilyloxylcyclohexene

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (3R,5S,2'R)-3-dimethyl(phenyl)silyl-5-methyl-2-(6'-methylhept-2'-yl)-1-trimethysilyloxylcyclohexene

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (3R,5S,2'R)-3-dimethyl(phenyl)silyl-5-methyl-2-(6'-methylhept-2'-yl)-1-trimethysilyloxylcyclohexene

There total 8 articles about (3R,5S,2'R)-3-dimethyl(phenyl)silyl-5-methyl-2-(6'-methylhept-2'-yl)-1-trimethysilyloxylcyclohexene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 75-77-4
chloro-trimethyl-silane

: 626-88-0
1-bromo-5-methylpentane

: 679841-33-9
(3R,5S,1'Z)-2-ethylidene-3-dimethyl(phenyl)silyl-5-methylcyclohexanone

: 679841-63-5
(3R,5S,2'R)-3-dimethyl(phenyl)silyl-5-methyl-2-(6'-methylhept-2'-yl)-1-trimethysilyloxylcyclohexene

Guidance literature:: 1-bromo-5-methylpentane; With lithium; In tetrahydrofuran;

With copper(I) bromide dimethylsulfide complex; In tetrahydrofuran; at -20 ℃; for 0.5h;

chloro-trimethyl-silane; (3R,5S,1'Z)-2-ethylidene-3-dimethyl(phenyl)silyl-5-methylcyclohexanone; In tetrahydrofuran; diethyl ether; at -78 - 0 ℃; for 1h; Further stages.;
DOI:10.1039/b305880h

Reference yield:

: 768-33-2
phenyldimethylsilyl chloride

: 679841-63-5
(3R,5S,2'R)-3-dimethyl(phenyl)silyl-5-methyl-2-(6'-methylhept-2'-yl)-1-trimethysilyloxylcyclohexene

Guidance literature:: Multi-step reaction with 4 steps

1.1: 92 percent / N,N-4-dimethylaminopyridine; pyridine / CH₂Cl₂ / 12 h / 0 °C

2.1: 98 percent / DBU / dimethylformamide / 5 h / 100 °C

3.1: Li / tetrahydrofuran

3.2: CuBr*Me₂S / tetrahydrofuran / 0.5 h / -20 °C

3.3: 670 mg / tetrahydrofuran; diethyl ether / 1 h / -78 - 0 °C

With pyridine; dmap; lithium; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1039/b305880h

Reference yield:

: 54307-74-3,15466-88-3
(R)-5-methyl-cyclohex-2-enone

: 679841-63-5
(3R,5S,2'R)-3-dimethyl(phenyl)silyl-5-methyl-2-(6'-methylhept-2'-yl)-1-trimethysilyloxylcyclohexene

Guidance literature:: Multi-step reaction with 4 steps

1.1: 74 percent / Et₂AlI / hexane; CH₂Cl₂ / 0.5 h / 0 °C

2.1: n-BuLi / hexane; tetrahydrofuran / 1 h / -78 - 0 °C

2.2: 95 percent / hexane; tetrahydrofuran / 2 h / 0 - 20 °C

3.1: Li / tetrahydrofuran / 26 h

3.2: CuI / tetrahydrofuran / 0.33 h / -20 °C

3.3: 169 mg / tetrahydrofuran / 1 h / -20 °C

4.1: Li / tetrahydrofuran

4.2: CuBr*Me₂S / tetrahydrofuran / 0.5 h / -20 °C

4.3: 670 mg / tetrahydrofuran; diethyl ether / 1 h / -78 - 0 °C

With n-butyllithium; diethylaluminum iodide; lithium; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1039/b305880h