1H-Pyrrolo[2,3-b]pyridine-3-carboxylic acid, 5-fluoro-2-Methyl-1-(phenylsulfonyl)-, Methyl ester

Base Information

Chemical Name:1H-Pyrrolo[2,3-b]pyridine-3-carboxylic acid, 5-fluoro-2-Methyl-1-(phenylsulfonyl)-, Methyl ester
CAS No.:1312755-48-8
Molecular Formula:C₁₆H₁₃FN₂O₄S
Molecular Weight:348.355
Hs Code.:
Mol file:1312755-48-8.mol

Synonyms:1-benzenesulfonyl-5-fluoro-2-methyl-1H-pyrrolo[2,3-b]pyridine-3-carboxylic acid methyl ester

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Chemical Property of 1H-Pyrrolo[2,3-b]pyridine-3-carboxylic acid, 5-fluoro-2-Methyl-1-(phenylsulfonyl)-, Methyl ester

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Technology Process of 1H-Pyrrolo[2,3-b]pyridine-3-carboxylic acid, 5-fluoro-2-Methyl-1-(phenylsulfonyl)-, Methyl ester

There total 5 articles about 1H-Pyrrolo[2,3-b]pyridine-3-carboxylic acid, 5-fluoro-2-Methyl-1-(phenylsulfonyl)-, Methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 1312755-47-7
5-fluoro-2-methyl-1H-pyrrolo[2,3-b]pyridine-3-carboxylic acid methyl ester

: 98-09-9
benzenesulfonyl chloride

: 1312755-48-8
1-benzenesulfonyl-5-fluoro-2-methyl-1H-pyrrolo[2,3-b]pyridine-3-carboxylic acid methyl ester

Guidance literature:: With N-benzyl-N,N,N-triethylammonium chloride; sodium hydroxide; In dichloromethane; at 0 - 20 ℃;

Reference yield:

: 145934-92-5
5-fluoro-2-methyl-1H-pyrrolo[2,3-b]pyridine

: 1312755-48-8
1-benzenesulfonyl-5-fluoro-2-methyl-1H-pyrrolo[2,3-b]pyridine-3-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: aluminum (III) chloride / dichloromethane / 0.83 h

1.2: 18 h

2.1: sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride / dichloromethane / 0 - 20 °C

With N-benzyl-N,N,N-triethylammonium chloride; sodium hydroxide; aluminum (III) chloride; In dichloromethane;

Reference yield:

: 21717-96-4
2-amino-5-fluoropyridine

: 1312755-48-8
1-benzenesulfonyl-5-fluoro-2-methyl-1H-pyrrolo[2,3-b]pyridine-3-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: sulfuric acid; potassium iodate / 100 °C

1.2: 1.5 h

2.1: triethylamine / copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 1 h / 0 - 20 °C

3.1: potassium tert-butylate / tert-butyl alcohol / 1 h / 85 °C

4.1: aluminum (III) chloride / dichloromethane / 0.83 h

4.2: 18 h

5.1: sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride / dichloromethane / 0 - 20 °C

With potassium iodate; sulfuric acid; potassium tert-butylate; N-benzyl-N,N,N-triethylammonium chloride; triethylamine; sodium hydroxide; aluminum (III) chloride; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In tetrahydrofuran; dichloromethane; tert-butyl alcohol;