<4S,3(2R)>-4-benzyl-3-<4-((tert-butoxycarbonyl)amino)-2-methylbutanoyl>-2-oxazolidinone

Base Information

Chemical Name:<4S,3(2R)>-4-benzyl-3-<4-((tert-butoxycarbonyl)amino)-2-methylbutanoyl>-2-oxazolidinone
CAS No.:139462-30-9
Molecular Formula:C₂₀H₂₈N₂O₅
Molecular Weight:376.453
Hs Code.:

Synonyms:<4S,3(2R)>-4-benzyl-3-<4-((tert-butoxycarbonyl)amino)-2-methylbutanoyl>-2-oxazolidinone

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Chemical Property of <4S,3(2R)>-4-benzyl-3-<4-((tert-butoxycarbonyl)amino)-2-methylbutanoyl>-2-oxazolidinone

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Technology Process of <4S,3(2R)>-4-benzyl-3-<4-((tert-butoxycarbonyl)amino)-2-methylbutanoyl>-2-oxazolidinone

There total 4 articles about <4S,3(2R)>-4-benzyl-3-<4-((tert-butoxycarbonyl)amino)-2-methylbutanoyl>-2-oxazolidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 139462-29-6
(R)-5-((S)-4-benzyl-2-oxooxazolidin-3-yl)-4-methyl-5-oxopentanoic acid

: 75-65-0
tert-butyl alcohol

: 139462-30-9
<4S,3(2R)>-4-benzyl-3-<4-((tert-butoxycarbonyl)amino)-2-methylbutanoyl>-2-oxazolidinone

Guidance literature:: With diphenylphosphoranyl azide; triethylamine; for 15h; Heating;
DOI:10.1021/ja00050a024

Reference yield:

: 131685-53-5,101711-78-8
(S)-4-benzyl-3-propionyl-2-oxazolidinone

: 139462-30-9
<4S,3(2R)>-4-benzyl-3-<4-((tert-butoxycarbonyl)amino)-2-methylbutanoyl>-2-oxazolidinone

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) titanium(IV) isopropoxide, titanium tetrachloride, diisopropylethylamine / 1.) CH₂Cl₂, 0 deg C, 1 h, 2.) CH₂Cl₂, 0 deg C, 4 h

2: 100 percent / TFA / CH₂Cl₂

3: 71 percent / Et₃N, diphenylphosphoryl azide / 15 h / Heating

With titanium(IV) isopropylate; diphenylphosphoranyl azide; titanium tetrachloride; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane;
DOI:10.1021/ja00050a024

Reference yield:

: 136546-79-7
<4S,3(2R)>-4-benzyl-3-<4-(tert-butoxycarbonyl)-2-methylbutanoyl>-2-oxazolidinone

: 139462-30-9
<4S,3(2R)>-4-benzyl-3-<4-((tert-butoxycarbonyl)amino)-2-methylbutanoyl>-2-oxazolidinone

Guidance literature:: Multi-step reaction with 2 steps

1: 100 percent / TFA / CH₂Cl₂

2: 71 percent / Et₃N, diphenylphosphoryl azide / 15 h / Heating

With diphenylphosphoranyl azide; triethylamine; trifluoroacetic acid; In dichloromethane;
DOI:10.1021/ja00050a024