2-bromo-N-ethyl-acetamide

Base Information

• Chemical Name: 2-bromo-N-ethyl-acetamide
• CAS No.: 5327-00-4
• Molecular Formula: C4H8BrNO
• Molecular Weight: 166.018
• Hs Code.: 2924199090
• Mol file: 5327-00-4.mol

Synonyms:N-Ethylbromoacetamide;NSC 4095;

Chemical Property of 2-bromo-N-ethyl-acetamide

Chemical Property:

• Vapor Pressure: 0.00648mmHg at 25°C
• Refractive Index: 1.473
• Boiling Point: 271.3 °C at 760 mmHg
• Flash Point: 117.9 °C
• PSA: 29.10000
• Density: 1.46 g/cm³
• LogP: 0.90830

Purity/Quality:

98%min ^*data from raw suppliers

2-bromo-N-ethylacetamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-bromo-N-ethyl-acetamide

There total 2 articles about 2-bromo-N-ethyl-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

ethylamine (75-04-7,85404-22-4) + 2-Bromoacetyl bromide (598-21-0) → N-ethyl-2-bromoacetamide (5327-00-4)

Guidance literature:

With potassium carbonate; In dichloromethane; water; at 5 ℃; for 17.5h;

DOI:10.1039/C8OB01981A

Reference yield:

ethanamine hydrochloride (557-66-4) + 2-Bromoacetyl bromide (598-21-0) → N-ethyl-2-bromoacetamide (5327-00-4)

Guidance literature:

With potassium carbonate;

DOI:10.1021/jo050783c

Reference yield: 83.0%

N-ethyl-2-bromoacetamide (5327-00-4) + 6-(3-fluoro-4-methoxybenzyl)-2,3,4,7-tetrahydro-1H-indolo[2,3-c][1,7]naphthyridine (1207632-14-1) → N-ethyl-2-[6-(3-fluoro-4-methoxybenzyl)-1,2,4,7-tetrahydro-3H-indolo[2,3-c][1,7]naphthyridin-3-yl]acetamide (1207634-49-8)

Guidance literature:

With potassium carbonate; In acetone; at 20 ℃; for 20h;

upstream raw materials:

ethylamine

2-Bromoacetyl bromide

ethanamine hydrochloride

Downstream raw materials:

2-(2,6-Diethyl-phenylamino)-N-ethyl-acetamide

2'-(4-mercapto-1-phenylpyrazolo[3,4-d]pyrimidin-6-ylthio)-N-ethyl-ethanamide

2-{[6-Amino-3,5-dicyano-4-(4-hydroxyphenyl)-2-pyridinyl]sulfanyl}-N-ethylacetamide

N-ethyl-2-[(4-methoxyphenyl)amino]acetamide