Technology Process of 6-chloro-9-(2’,5’-di-O-benzoyl-3’-azido-3’-deoxy-β-D-ribofuranosyl)purine
There total 1 articles about 6-chloro-9-(2’,5’-di-O-benzoyl-3’-azido-3’-deoxy-β-D-ribofuranosyl)purine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
C31H25N3O7; 6-chloropurine;
In
dichloromethane;
at 20 ℃;
for 1h;
Inert atmosphere;
Molecular sieve;
With
[bis(trifluoromethanesulfonyl)imidate](triphenylphosphine)gold(I);
In
dichloromethane;
for 2h;
Inert atmosphere;
Molecular sieve;
DOI:10.1021/ja501460j
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: ethanol; water / 8 h / 20 - 90 °C / Inert atmosphere
2.1: pyridine / 1.5 h / 20 °C / Inert atmosphere
3.1: triphenylphosphine; silica gel; water / tetrahydrofuran / 4 h / 20 - 50 °C / Inert atmosphere
4.1: N-ethyl-N,N-diisopropylamine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 20 °C / Inert atmosphere
5.1: triethylamine / dichloromethane / 5 h / 20 °C / Inert atmosphere
6.1: lithium borohydride / tetrahydrofuran / -40 - 20 °C / Inert atmosphere
7.1: dichloromethane / 1 h / 20 °C / Inert atmosphere; Molecular sieve
7.2: 1.5 h / 0 °C / Inert atmosphere; Molecular sieve
8.1: sodium methylate / methanol; dichloromethane / 8 h / 20 °C / Inert atmosphere
With
pyridine; lithium borohydride; water; sodium methylate; silica gel; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine;
In
tetrahydrofuran; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/ja501460j
- Guidance literature:
-
In
ethanol; water;
at 20 - 90 ℃;
for 8h;
Inert atmosphere;
DOI:10.1021/ja501460j
