Technology Process of 1-(4,4'-dimethoxytrityloxy)-29-[N-(1-benzyloxycarbonylamino)butyl]carbamoylmethylenoxy-3,6,9,12,15,18,21,24,27-nonaoxanonacosane
There total 5 articles about 1-(4,4'-dimethoxytrityloxy)-29-[N-(1-benzyloxycarbonylamino)butyl]carbamoylmethylenoxy-3,6,9,12,15,18,21,24,27-nonaoxanonacosane which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
(4,4'-dimethoxytrityl)decaethylene glycol;
With
sodium hydride;
In
acetonitrile;
at 20 ℃;
for 0.0833333h;
N-(benzyloxycarbonyl)-N'-(bromoacetyl)-1,4-diaminobutane;
In
acetonitrile;
at 40 ℃;
for 1.5h;
DOI:10.1021/ja051179m
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: 79 percent / triethylamine; 4-dimethylaminopyridine / CH2Cl2 / 16 h / 20 °C
2.1: 99 percent / triethylamine; 4-dimethylaminopyridine / CH2Cl2 / 12 h / 0 - 20 °C
3.1: NaH / dimethylformamide / 0.42 h / 0 - 20 °C
3.2: 73 percent / dimethylformamide / 20 h / 20 °C
4.1: NaH / acetonitrile / 0.08 h / 20 °C
4.2: 62 percent / acetonitrile / 1.5 h / 40 °C
With
dmap; sodium hydride; triethylamine;
In
dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/ja051179m
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: 79 percent / triethylamine; 4-dimethylaminopyridine / CH2Cl2 / 16 h / 20 °C
2.1: 99 percent / triethylamine; 4-dimethylaminopyridine / CH2Cl2 / 12 h / 0 - 20 °C
3.1: NaH / dimethylformamide / 0.42 h / 0 - 20 °C
3.2: 73 percent / dimethylformamide / 20 h / 20 °C
4.1: NaH / acetonitrile / 0.08 h / 20 °C
4.2: 62 percent / acetonitrile / 1.5 h / 40 °C
With
dmap; sodium hydride; triethylamine;
In
dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/ja051179m
