Technology Process of 2-phenyl-6-({3-[1-(1,3-thiazol-2-ylcarbonyl)piperidin-4-yl]azetidin-1-yl}carbonyl)-1,3-benzoxazole
There total 9 articles about 2-phenyl-6-({3-[1-(1,3-thiazol-2-ylcarbonyl)piperidin-4-yl]azetidin-1-yl}carbonyl)-1,3-benzoxazole which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
(4-(azetidin-3-yl)piperidin-1-yl)(thiazol-2-yl)methanone; 2-phenylbenzo[d]oxazole-6-carboxylic acid;
With
triethylamine;
In
dichloromethane;
at 20 ℃;
for 0.333333h;
With
HATU;
In
dichloromethane;
at 20 ℃;
for 20h;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: sodium tetrahydroborate; sodium hydrogencarbonate / ethanol / 1.17 h / 0 - 20 °C / Inert atmosphere
2.1: hydrogen; palladium(II) hydroxide / ethanol / 96 h / 20 °C / 2585.81 Torr / Inert atmosphere
3.1: triethylamine / dichloromethane / 0.33 h / 20 °C
3.2: 5 h / 20 °C
4.1: trifluoroacetic acid / dichloromethane / 5 h / 20 °C
5.1: triethylamine / dichloromethane / 0.33 h / 20 °C
5.2: 20 h / 20 °C
With
sodium tetrahydroborate; hydrogen; palladium(II) hydroxide; sodium hydrogencarbonate; triethylamine; trifluoroacetic acid;
In
ethanol; dichloromethane;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: chloro-trimethyl-silane; ethylene dibromide; zinc / N,N-dimethyl acetamide / 1.5 h / 20 - 65 °C / Inert atmosphere
1.2: 2 h / 80 °C / Inert atmosphere
2.1: acetonitrile / 1 h / 80 °C / Inert atmosphere
3.1: sodium tetrahydroborate; sodium hydrogencarbonate / ethanol / 1.17 h / 0 - 20 °C / Inert atmosphere
4.1: hydrogen; palladium(II) hydroxide / ethanol / 96 h / 20 °C / 2585.81 Torr / Inert atmosphere
5.1: triethylamine / dichloromethane / 0.33 h / 20 °C
5.2: 5 h / 20 °C
6.1: trifluoroacetic acid / dichloromethane / 5 h / 20 °C
7.1: triethylamine / dichloromethane / 0.33 h / 20 °C
7.2: 20 h / 20 °C
With
sodium tetrahydroborate; chloro-trimethyl-silane; hydrogen; palladium(II) hydroxide; sodium hydrogencarbonate; ethylene dibromide; triethylamine; trifluoroacetic acid; zinc;
In
ethanol; dichloromethane; N,N-dimethyl acetamide; acetonitrile;
