(E)-methyl 2-{[3-(2-[(tert-butyldimethylsilyloxy)ethyl])-1-(phenylsulfonyl)-1H-indol-2-yl]methylene}aminoacetate

Base Information

Chemical Name:(E)-methyl 2-{[3-(2-[(tert-butyldimethylsilyloxy)ethyl])-1-(phenylsulfonyl)-1H-indol-2-yl]methylene}aminoacetate
CAS No.:1416081-13-4
Molecular Formula:C₂₆H₃₄N₂O₅SSi
Molecular Weight:514.718
Hs Code.:

Synonyms:(E)-methyl 2-{[3-(2-[(tert-butyldimethylsilyloxy)ethyl])-1-(phenylsulfonyl)-1H-indol-2-yl]methylene}aminoacetate

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Chemical Property of (E)-methyl 2-{[3-(2-[(tert-butyldimethylsilyloxy)ethyl])-1-(phenylsulfonyl)-1H-indol-2-yl]methylene}aminoacetate

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Technology Process of (E)-methyl 2-{[3-(2-[(tert-butyldimethylsilyloxy)ethyl])-1-(phenylsulfonyl)-1H-indol-2-yl]methylene}aminoacetate

There total 4 articles about (E)-methyl 2-{[3-(2-[(tert-butyldimethylsilyloxy)ethyl])-1-(phenylsulfonyl)-1H-indol-2-yl]methylene}aminoacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5680-79-5,883886-67-7
glycine ethyl ester hydrochloride

: 411208-90-7
3-(2-((tert-butyldimethylsilyl)oxy)ethyl)-1-(phenylsulfonyl)-1H-indole-2-carbaldehyde

: 1416081-13-4
(E)-methyl 2-{[3-(2-[(tert-butyldimethylsilyloxy)ethyl])-1-(phenylsulfonyl)-1H-indol-2-yl]methylene}aminoacetate

Guidance literature:: With magnesium sulfate; triethylamine; In chloroform; for 16h; Darkness; Reflux;
DOI:10.1016/j.tetasy.2012.10.015

Reference yield:

: 526-55-6,930395-07-6
2-(3-indole)-ethanol

: 1416081-13-4
(E)-methyl 2-{[3-(2-[(tert-butyldimethylsilyloxy)ethyl])-1-(phenylsulfonyl)-1H-indol-2-yl]methylene}aminoacetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: 1H-imidazole / N,N-dimethyl-formamide / 16 h / 26 °C / Darkness

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 - 25 °C / Darkness

2.2: 19 h / 25 °C

3.1: n-butyllithium / tetrahydrofuran; hexane / 2 h / -78 °C / Darkness

3.2: -78 - 25 °C / Darkness

4.1: triethylamine; magnesium sulfate / chloroform / 16 h / Darkness; Reflux

With 1H-imidazole; n-butyllithium; sodium hydride; magnesium sulfate; triethylamine; In tetrahydrofuran; hexane; chloroform; N,N-dimethyl-formamide; mineral oil;
DOI:10.1016/j.tetasy.2012.10.015

Reference yield:

: 101079-48-5
3-(2-((tert-butyldimethylsilyl)oxy)ethyl)-1H-indole

: 1416081-13-4
(E)-methyl 2-{[3-(2-[(tert-butyldimethylsilyloxy)ethyl])-1-(phenylsulfonyl)-1H-indol-2-yl]methylene}aminoacetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 - 25 °C / Darkness

1.2: 19 h / 25 °C

2.1: n-butyllithium / tetrahydrofuran; hexane / 2 h / -78 °C / Darkness

2.2: -78 - 25 °C / Darkness

3.1: triethylamine; magnesium sulfate / chloroform / 16 h / Darkness; Reflux

With n-butyllithium; sodium hydride; magnesium sulfate; triethylamine; In tetrahydrofuran; hexane; chloroform; N,N-dimethyl-formamide; mineral oil;
DOI:10.1016/j.tetasy.2012.10.015