(S)-ethyl 3-amino-3-(3-chloro-5-(4-(methoxymethyl)tetrahydro-2H-pyran-4-yl)phenyl)propanoate hydrochloride

Base Information

Chemical Name:(S)-ethyl 3-amino-3-(3-chloro-5-(4-(methoxymethyl)tetrahydro-2H-pyran-4-yl)phenyl)propanoate hydrochloride
CAS No.:1541198-03-1
Molecular Formula:C₁₈H₂₆ClNO₄*ClH
Molecular Weight:392.323
Hs Code.:

Synonyms:(S)-ethyl 3-amino-3-(3-chloro-5-(4-(methoxymethyl)tetrahydro-2H-pyran-4-yl)phenyl)propanoate hydrochloride

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Chemical Property of (S)-ethyl 3-amino-3-(3-chloro-5-(4-(methoxymethyl)tetrahydro-2H-pyran-4-yl)phenyl)propanoate hydrochloride

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Technology Process of (S)-ethyl 3-amino-3-(3-chloro-5-(4-(methoxymethyl)tetrahydro-2H-pyran-4-yl)phenyl)propanoate hydrochloride

There total 9 articles about (S)-ethyl 3-amino-3-(3-chloro-5-(4-(methoxymethyl)tetrahydro-2H-pyran-4-yl)phenyl)propanoate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1541198-10-0
C₂₃H₃₄ClNO₆

: 1541198-03-1
(S)-ethyl 3-amino-3-(3-chloro-5-(4-(methoxymethyl)tetrahydro-2H-pyran-4-yl)phenyl)propanoate hydrochloride

Guidance literature:: With hydrogenchloride; In ethyl acetate; for 1h;

Reference yield:

: 230642-94-1
2-(3-chloro-5-formylphenyl)-2-methylpropanenitrile

: 1541198-03-1
(S)-ethyl 3-amino-3-(3-chloro-5-(4-(methoxymethyl)tetrahydro-2H-pyran-4-yl)phenyl)propanoate hydrochloride

Guidance literature:: Multi-step reaction with 8 steps

1.1: n-butyllithium; N-cyclohexyl-cyclohexanamine / hexane; toluene / 0.08 h / 0 - 25 °C / Inert atmosphere

1.2: 1 h / Inert atmosphere

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / 25 °C

3.1: sodium hydride / tetrahydrofuran / 0.17 h / 25 °C / Inert atmosphere

3.2: 1 h / 80 °C / Inert atmosphere

4.1: toluene-4-sulfonic acid / acetone / 20 °C / Inert atmosphere

5.1: ammonium acetate / ethanol / 7 h / Reflux

6.1: 2,6-dimethylpyridine / dichloromethane / 10 h / 20 °C

7.1: Resolution of racemate

8.1: hydrogenchloride / ethyl acetate / 1 h

With 2,6-dimethylpyridine; hydrogenchloride; lithium aluminium tetrahydride; n-butyllithium; ammonium acetate; sodium hydride; toluene-4-sulfonic acid; N-cyclohexyl-cyclohexanamine; In tetrahydrofuran; ethanol; hexane; dichloromethane; ethyl acetate; acetone; toluene;

Reference yield:

: 188813-05-0
3-bromo-5-chloro-benzaldehyde

: 1541198-03-1
(S)-ethyl 3-amino-3-(3-chloro-5-(4-(methoxymethyl)tetrahydro-2H-pyran-4-yl)phenyl)propanoate hydrochloride

Guidance literature:: Multi-step reaction with 9 steps

1.1: toluene-4-sulfonic acid / toluene / 6 h / Reflux; Dean-Stark

2.1: n-butyllithium; N-cyclohexyl-cyclohexanamine / hexane; toluene / 0.08 h / 0 - 25 °C / Inert atmosphere

2.2: 1 h / Inert atmosphere

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / 25 °C

4.1: sodium hydride / tetrahydrofuran / 0.17 h / 25 °C / Inert atmosphere

4.2: 1 h / 80 °C / Inert atmosphere

5.1: toluene-4-sulfonic acid / acetone / 20 °C / Inert atmosphere

6.1: ammonium acetate / ethanol / 7 h / Reflux

7.1: 2,6-dimethylpyridine / dichloromethane / 10 h / 20 °C

8.1: Resolution of racemate

9.1: hydrogenchloride / ethyl acetate / 1 h

With 2,6-dimethylpyridine; hydrogenchloride; lithium aluminium tetrahydride; n-butyllithium; ammonium acetate; sodium hydride; toluene-4-sulfonic acid; N-cyclohexyl-cyclohexanamine; In tetrahydrofuran; ethanol; hexane; dichloromethane; ethyl acetate; acetone; toluene;