(3S)-3-(3-chloro-5-(4-(methoxymethyl)tetrahydro-2H-pyran-4-yl)phenyl)-3-(2-(3-hydroxy-5-((5-hydroxy-1,4,5,6-tetrahydropyrimidin-2-yl)amino)benzamido)acetamido)propanoic acid

Base Information

Chemical Name:(3S)-3-(3-chloro-5-(4-(methoxymethyl)tetrahydro-2H-pyran-4-yl)phenyl)-3-(2-(3-hydroxy-5-((5-hydroxy-1,4,5,6-tetrahydropyrimidin-2-yl)amino)benzamido)acetamido)propanoic acid
CAS No.:1541197-21-0
Molecular Formula:C₂₉H₃₆ClN₅O₈
Molecular Weight:618.087
Hs Code.:

(3S)-3-(3-chloro-5-(4-(methoxymethyl)tetrahydro-2H-pyran-4-yl)phenyl)-3-(2-(3-hydroxy-5-((5-hydroxy-1,4,5,6-tetrahydropyrimidin-2-yl)amino)benzamido)acetamido)propanoic acid

Synonyms:(3S)-3-(3-chloro-5-(4-(methoxymethyl)tetrahydro-2H-pyran-4-yl)phenyl)-3-(2-(3-hydroxy-5-((5-hydroxy-1,4,5,6-tetrahydropyrimidin-2-yl)amino)benzamido)acetamido)propanoic acid

Suppliers and Price of (3S)-3-(3-chloro-5-(4-(methoxymethyl)tetrahydro-2H-pyran-4-yl)phenyl)-3-(2-(3-hydroxy-5-((5-hydroxy-1,4,5,6-tetrahydropyrimidin-2-yl)amino)benzamido)acetamido)propanoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (3S)-3-(3-chloro-5-(4-(methoxymethyl)tetrahydro-2H-pyran-4-yl)phenyl)-3-(2-(3-hydroxy-5-((5-hydroxy-1,4,5,6-tetrahydropyrimidin-2-yl)amino)benzamido)acetamido)propanoic acid

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (3S)-3-(3-chloro-5-(4-(methoxymethyl)tetrahydro-2H-pyran-4-yl)phenyl)-3-(2-(3-hydroxy-5-((5-hydroxy-1,4,5,6-tetrahydropyrimidin-2-yl)amino)benzamido)acetamido)propanoic acid

There total 14 articles about (3S)-3-(3-chloro-5-(4-(methoxymethyl)tetrahydro-2H-pyran-4-yl)phenyl)-3-(2-(3-hydroxy-5-((5-hydroxy-1,4,5,6-tetrahydropyrimidin-2-yl)amino)benzamido)acetamido)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1541199-12-5
(3S)-ethyl 3-(3-chloro-5-(4-(methoxymethyl)tetrahydro-2H-pyran-4-yl)phenyl)-3-(2-(3-hydroxy-5-((5-hydroxy-1,4,5,6-tetrahydropyrimidin-2-yl)amino)benzamido)acetamido)propanoate

: 1541197-21-0
(3S)-3-(3-chloro-5-(4-(methoxymethyl)tetrahydro-2H-pyran-4-yl)phenyl)-3-(2-(3-hydroxy-5-((5-hydroxy-1,4,5,6-tetrahydropyrimidin-2-yl)amino)benzamido)acetamido)propanoic acid

Guidance literature:: With lithium hydroxide monohydrate; In water; acetonitrile; at 20 ℃;

Reference yield:

: 230642-94-1
2-(3-chloro-5-formylphenyl)-2-methylpropanenitrile

: 1541197-21-0
(3S)-3-(3-chloro-5-(4-(methoxymethyl)tetrahydro-2H-pyran-4-yl)phenyl)-3-(2-(3-hydroxy-5-((5-hydroxy-1,4,5,6-tetrahydropyrimidin-2-yl)amino)benzamido)acetamido)propanoic acid

Guidance literature:: Multi-step reaction with 10 steps

1.1: n-butyllithium; N-cyclohexyl-cyclohexanamine / hexane; toluene / 0.08 h / 0 - 25 °C / Inert atmosphere

1.2: 1 h / Inert atmosphere

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / 25 °C

3.1: sodium hydride / tetrahydrofuran / 0.17 h / 25 °C / Inert atmosphere

3.2: 1 h / 80 °C / Inert atmosphere

4.1: toluene-4-sulfonic acid / acetone / 20 °C / Inert atmosphere

5.1: ammonium acetate / ethanol / 7 h / Reflux

6.1: 2,6-dimethylpyridine / dichloromethane / 10 h / 20 °C

7.1: Resolution of racemate

8.1: hydrogenchloride / ethyl acetate / 1 h

9.1: benzotriazol-1-ol / N,N-dimethyl-formamide; dichloromethane / 0.17 h / 20 °C / Inert atmosphere

9.2: 20 °C / Inert atmosphere

10.1: lithium hydroxide monohydrate / acetonitrile; water / 20 °C

With 2,6-dimethylpyridine; hydrogenchloride; lithium aluminium tetrahydride; n-butyllithium; lithium hydroxide monohydrate; ammonium acetate; sodium hydride; benzotriazol-1-ol; toluene-4-sulfonic acid; N-cyclohexyl-cyclohexanamine; In tetrahydrofuran; ethanol; hexane; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; acetone; toluene; acetonitrile;

Reference yield:

: 14862-52-3
1,3-dibromo-5-chlorobenzene

: 1541197-21-0
(3S)-3-(3-chloro-5-(4-(methoxymethyl)tetrahydro-2H-pyran-4-yl)phenyl)-3-(2-(3-hydroxy-5-((5-hydroxy-1,4,5,6-tetrahydropyrimidin-2-yl)amino)benzamido)acetamido)propanoic acid

Guidance literature:: Multi-step reaction with 12 steps

1.1: n-butyllithium / hexane; di-isopropyl ether / 0.5 h / -78 °C / Inert atmosphere

1.2: -78 °C / Inert atmosphere

2.1: toluene-4-sulfonic acid / toluene / 6 h / Reflux; Dean-Stark

3.1: n-butyllithium; N-cyclohexyl-cyclohexanamine / hexane; toluene / 0.08 h / 0 - 25 °C / Inert atmosphere

3.2: 1 h / Inert atmosphere

4.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / 25 °C

5.1: sodium hydride / tetrahydrofuran / 0.17 h / 25 °C / Inert atmosphere

5.2: 1 h / 80 °C / Inert atmosphere

6.1: toluene-4-sulfonic acid / acetone / 20 °C / Inert atmosphere

7.1: ammonium acetate / ethanol / 7 h / Reflux

8.1: 2,6-dimethylpyridine / dichloromethane / 10 h / 20 °C

9.1: Resolution of racemate

10.1: hydrogenchloride / ethyl acetate / 1 h

11.1: benzotriazol-1-ol / N,N-dimethyl-formamide; dichloromethane / 0.17 h / 20 °C / Inert atmosphere

11.2: 20 °C / Inert atmosphere

12.1: lithium hydroxide monohydrate / acetonitrile; water / 20 °C

With 2,6-dimethylpyridine; hydrogenchloride; lithium aluminium tetrahydride; n-butyllithium; lithium hydroxide monohydrate; ammonium acetate; sodium hydride; benzotriazol-1-ol; toluene-4-sulfonic acid; N-cyclohexyl-cyclohexanamine; In tetrahydrofuran; ethanol; hexane; dichloromethane; di-isopropyl ether; water; ethyl acetate; N,N-dimethyl-formamide; acetone; toluene; acetonitrile;