4-(6-(2-ethyl-1-(1H-imidazol-1-yl)butyl)benzo[d]thiazol-2-yl)benzoic acid

Base Information

Chemical Name:4-(6-(2-ethyl-1-(1H-imidazol-1-yl)butyl)benzo[d]thiazol-2-yl)benzoic acid
CAS No.:1351956-93-8
Molecular Formula:C₂₃H₂₃N₃O₂S
Molecular Weight:405.521
Hs Code.:

Synonyms:4-(6-(2-ethyl-1-(1H-imidazol-1-yl)butyl)benzo[d]thiazol-2-yl)benzoic acid

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Chemical Property of 4-(6-(2-ethyl-1-(1H-imidazol-1-yl)butyl)benzo[d]thiazol-2-yl)benzoic acid

Chemical Property:

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Technology Process of 4-(6-(2-ethyl-1-(1H-imidazol-1-yl)butyl)benzo[d]thiazol-2-yl)benzoic acid

There total 9 articles about 4-(6-(2-ethyl-1-(1H-imidazol-1-yl)butyl)benzo[d]thiazol-2-yl)benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1351956-92-7
methyl 4-(6-(2-ethyl-1-(1H-imidazol-1-yl)butyl)benzo[d]thiazol-2-yl)benzoate

: 1351956-93-8
4-(6-(2-ethyl-1-(1H-imidazol-1-yl)butyl)benzo[d]thiazol-2-yl)benzoic acid

Guidance literature:: methyl 4-(6-(2-ethyl-1-(1H-imidazol-1-yl)butyl)benzo[d]thiazol-2-yl)benzoate; With water; lithium hydroxide; In 1,4-dioxane; at 50 ℃;

With hydrogenchloride; In water; pH=7;

Reference yield:

: N-(4-(2-ethyl-1-hydroxybutyl)phenyl)acetamide

: 1351956-93-8
4-(6-(2-ethyl-1-(1H-imidazol-1-yl)butyl)benzo[d]thiazol-2-yl)benzoic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: acetonitrile / 20 °C

2.1: hydrogenchloride / water / 60 °C

2.2: pH 12 - 14 / Cooling with ice

3.1: bromine / acetic acid

3.2: pH 12 / Cooling with ice

4.1: copper(ll) bromide; sodium nitrite; hydrogen bromide / acetonitrile; water / 2.5 h / -10 - 20 °C

5.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 6 h / 80 °C / Inert atmosphere

6.1: water; lithium hydroxide / 1,4-dioxane / 50 °C

6.2: pH 7

With hydrogenchloride; water; hydrogen bromide; bromine; potassium carbonate; copper(ll) bromide; lithium hydroxide; sodium nitrite; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; 1,2-dimethoxyethane; water; acetic acid; acetonitrile;

Reference yield:

: 13211-00-2
N-(4-butyrylphenyl)acetamide

: 1351956-93-8
4-(6-(2-ethyl-1-(1H-imidazol-1-yl)butyl)benzo[d]thiazol-2-yl)benzoic acid

Guidance literature:: Multi-step reaction with 8 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / 1 h / -78 °C

1.2: 20 °C

2.1: sodium tetrahydroborate / methanol / 20 °C / Cooling with ice; Inert atmosphere

3.1: acetonitrile / 20 °C

4.1: hydrogenchloride / water / 60 °C

4.2: pH 12 - 14 / Cooling with ice

5.1: bromine / acetic acid

5.2: pH 12 / Cooling with ice

6.1: copper(ll) bromide; sodium nitrite; hydrogen bromide / acetonitrile; water / 2.5 h / -10 - 20 °C

7.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 6 h / 80 °C / Inert atmosphere

8.1: water; lithium hydroxide / 1,4-dioxane / 50 °C

8.2: pH 7

With hydrogenchloride; sodium tetrahydroborate; water; hydrogen bromide; bromine; potassium carbonate; copper(ll) bromide; lithium hydroxide; lithium diisopropyl amide; sodium nitrite; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; methanol; 1,2-dimethoxyethane; water; acetic acid; acetonitrile;