7,8-bis(4-isopropoxyphenyl)-3-(4-methoxyphenyl)-1H-pyrrolo[2,1-c][1,4]oxazin-1-one

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Chemical Name:7,8-bis(4-isopropoxyphenyl)-3-(4-methoxyphenyl)-1H-pyrrolo[2,1-c][1,4]oxazin-1-one
CAS No.:1426329-86-3
Molecular Formula:C₃₂H₃₁NO₅
Molecular Weight:509.602
Hs Code.:

Synonyms:7,8-bis(4-isopropoxyphenyl)-3-(4-methoxyphenyl)-1H-pyrrolo[2,1-c][1,4]oxazin-1-one

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Chemical Property of 7,8-bis(4-isopropoxyphenyl)-3-(4-methoxyphenyl)-1H-pyrrolo[2,1-c][1,4]oxazin-1-one

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Technology Process of 7,8-bis(4-isopropoxyphenyl)-3-(4-methoxyphenyl)-1H-pyrrolo[2,1-c][1,4]oxazin-1-one

There total 5 articles about 7,8-bis(4-isopropoxyphenyl)-3-(4-methoxyphenyl)-1H-pyrrolo[2,1-c][1,4]oxazin-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 1426329-85-2
3,4-bis(4-isopropoxyphenyl)-1-[2-(4-methoxyphenyl)-2-oxoethyl]pyrrole-2-carboxylic acid

: 1426329-86-3
7,8-bis(4-isopropoxyphenyl)-3-(4-methoxyphenyl)-1H-pyrrolo[2,1-c][1,4]oxazin-1-one

Guidance literature:: With sodium acetate; In acetic anhydride; at 100 ℃; for 1h;
DOI:10.1016/j.tet.2013.01.077

Reference yield:

: 1426329-80-7
benzyl N-benzenesulfonyl-3,4-dibromopyrrole-2-carboxylate

: 1426329-86-3
7,8-bis(4-isopropoxyphenyl)-3-(4-methoxyphenyl)-1H-pyrrolo[2,1-c][1,4]oxazin-1-one

Guidance literature:: Multi-step reaction with 5 steps

1: bis(dibenzylideneacetone)-palladium⁽⁰⁾; 1,1'-bis(di-tertbutylphosphino)ferrocene; sodium carbonate / tetrahydrofuran; water / 14 h / Reflux; Inert atmosphere

2: tetrabutyl ammonium fluoride / tetrahydrofuran / 12 h / 20 °C / Reflux

3: potassium carbonate / N,N-dimethyl-formamide / 3 h / 70 °C / Inert atmosphere

4: palladium on carbon; hydrogen / ethyl acetate / 4 h / 20 °C

5: sodium acetate / acetic anhydride / 1 h / 100 °C

With 1,1'-bis(di-tertbutylphosphino)ferrocene; palladium on carbon; tetrabutyl ammonium fluoride; hydrogen; sodium acetate; sodium carbonate; potassium carbonate; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In tetrahydrofuran; water; acetic anhydride; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2013.01.077

Reference yield:

: 1426329-82-9
benzyl N-benzenesulfonyl-3,4-bis(4-isopropoxyphenyl)pyrrole-2-carboxylate

: 1426329-86-3
7,8-bis(4-isopropoxyphenyl)-3-(4-methoxyphenyl)-1H-pyrrolo[2,1-c][1,4]oxazin-1-one

Guidance literature:: Multi-step reaction with 4 steps

1: tetrabutyl ammonium fluoride / tetrahydrofuran / 12 h / 20 °C / Reflux

2: potassium carbonate / N,N-dimethyl-formamide / 3 h / 70 °C / Inert atmosphere

3: palladium on carbon; hydrogen / ethyl acetate / 4 h / 20 °C

4: sodium acetate / acetic anhydride / 1 h / 100 °C

With palladium on carbon; tetrabutyl ammonium fluoride; hydrogen; sodium acetate; potassium carbonate; In tetrahydrofuran; acetic anhydride; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2013.01.077