benzyl 3,4-bis(4-isopropoxyphenyl)-1-[2-(4-methoxyphenyl)-2-oxoethyl]pyrrole-2-carboxylate

Base Information

Chemical Name:benzyl 3,4-bis(4-isopropoxyphenyl)-1-[2-(4-methoxyphenyl)-2-oxoethyl]pyrrole-2-carboxylate
CAS No.:1426329-84-1
Molecular Formula:C₃₉H₃₉NO₆
Molecular Weight:617.742
Hs Code.:

Synonyms:benzyl 3,4-bis(4-isopropoxyphenyl)-1-[2-(4-methoxyphenyl)-2-oxoethyl]pyrrole-2-carboxylate

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Chemical Property of benzyl 3,4-bis(4-isopropoxyphenyl)-1-[2-(4-methoxyphenyl)-2-oxoethyl]pyrrole-2-carboxylate

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Technology Process of benzyl 3,4-bis(4-isopropoxyphenyl)-1-[2-(4-methoxyphenyl)-2-oxoethyl]pyrrole-2-carboxylate

There total 4 articles about benzyl 3,4-bis(4-isopropoxyphenyl)-1-[2-(4-methoxyphenyl)-2-oxoethyl]pyrrole-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 1426329-83-0
benzyl 3,4-bis(4-isopropoxyphenyl)-1H-pyrrole-2-carboxylate

: 2632-13-5
2-Bromo-4'-methoxyacetophenone

: 1426329-84-1
benzyl 3,4-bis(4-isopropoxyphenyl)-1-[2-(4-methoxyphenyl)-2-oxoethyl]pyrrole-2-carboxylate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 70 ℃; for 3h; Inert atmosphere;
DOI:10.1016/j.tet.2013.01.077

Reference yield:

: 501-53-1,94274-21-2
benzyl chloroformate

: 1426329-84-1
benzyl 3,4-bis(4-isopropoxyphenyl)-1-[2-(4-methoxyphenyl)-2-oxoethyl]pyrrole-2-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-butyllithium; diisopropylamine / hexane; tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

1.2: 1 h / 78 °C / Inert atmosphere

2.1: bis(dibenzylideneacetone)-palladium⁽⁰⁾; 1,1'-bis(di-tertbutylphosphino)ferrocene; sodium carbonate / tetrahydrofuran; water / 14 h / Reflux; Inert atmosphere

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 12 h / 20 °C / Reflux

4.1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 70 °C / Inert atmosphere

With n-butyllithium; 1,1'-bis(di-tertbutylphosphino)ferrocene; tetrabutyl ammonium fluoride; sodium carbonate; potassium carbonate; diisopropylamine; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In tetrahydrofuran; hexane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2013.01.077

Reference yield:

: 1426329-82-9
benzyl N-benzenesulfonyl-3,4-bis(4-isopropoxyphenyl)pyrrole-2-carboxylate

: 1426329-84-1
benzyl 3,4-bis(4-isopropoxyphenyl)-1-[2-(4-methoxyphenyl)-2-oxoethyl]pyrrole-2-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: tetrabutyl ammonium fluoride / tetrahydrofuran / 12 h / 20 °C / Reflux

2: potassium carbonate / N,N-dimethyl-formamide / 3 h / 70 °C / Inert atmosphere

With tetrabutyl ammonium fluoride; potassium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2013.01.077