N₈-(3-(9H-purin-6-yI)pyridin-2-yI)-N₄-(4-chIorophenyl)-7-methylquinazoline-4,8-diamine

Base Information

• Chemical Name: N₈-(3-(9H-purin-6-yI)pyridin-2-yI)-N₄-(4-chIorophenyl)-7-methylquinazoline-4,8-diamine
• CAS No.: 1093100-62-9
• Molecular Formula: C₂₅H₁₈ClN₉
• Molecular Weight: 479.931

Synonyms:N₈-(3-(9H-purin-6-yI)pyridin-2-yI)-N₄-(4-chIorophenyl)-7-methylquinazoline-4,8-diamine

Chemical Property of N₈-(3-(9H-purin-6-yI)pyridin-2-yI)-N₄-(4-chIorophenyl)-7-methylquinazoline-4,8-diamine

Chemical Property:

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Technology Process of N₈-(3-(9H-purin-6-yI)pyridin-2-yI)-N₄-(4-chIorophenyl)-7-methylquinazoline-4,8-diamine

There total 8 articles about N₈-(3-(9H-purin-6-yI)pyridin-2-yI)-N₄-(4-chIorophenyl)-7-methylquinazoline-4,8-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

7-methyl-4-(methylthio)-N-(3-(9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-yl)pyridin-2-yl)quinazolin-8-amine (1093101-67-7) + 4-chloro-aniline (106-47-8) → N8-(3-(9H-purin-6-yI)pyridin-2-yI)-N4-(4-chIorophenyl)-7-methylquinazoline-4,8-diamine (1093100-62-9)

Guidance literature:

With trifluoroacetic acid; In 1,4-dioxane; at 160 ℃; for 0.2h; microwave;

Reference yield:

7-methyl-quinazolin-4(3H)-one (75844-40-5) → N8-(3-(9H-purin-6-yI)pyridin-2-yI)-N4-(4-chIorophenyl)-7-methylquinazoline-4,8-diamine (1093100-62-9)

Guidance literature:

Multi-step reaction with 6 steps

1.1: methanol; acetic acid / 0.08 h / 20 °C

1.2: 3 h / 20 °C

2.1: sulfuric acid; nitric acid / 5.17 h / 0 - 20 °C

3.1: hydrogen / palladium 10% on activated carbon / ethanol / 96 h

4.1: Lawessons reagent; pyridine / 12 h / 100 °C

4.2: 0.5 h

5.1: lithium hexamethyldisilazane / tetrahydrofuran; 1,4-dioxane / 6 h / 20 °C

6.1: trifluoroacetic acid / 1,4-dioxane / 0.2 h / 160 °C / microwave

With Lawessons reagent; pyridine; methanol; sulfuric acid; hydrogen; nitric acid; acetic acid; trifluoroacetic acid; lithium hexamethyldisilazane; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; ethanol;

Reference yield:

6-bromo-7-methyl-8-nitroquinazolin-4(3H)-one (943605-86-5) → N8-(3-(9H-purin-6-yI)pyridin-2-yI)-N4-(4-chIorophenyl)-7-methylquinazoline-4,8-diamine (1093100-62-9)

Guidance literature:

Multi-step reaction with 4 steps

1.1: hydrogen / palladium 10% on activated carbon / ethanol / 96 h

2.1: Lawessons reagent; pyridine / 12 h / 100 °C

2.2: 0.5 h

3.1: lithium hexamethyldisilazane / tetrahydrofuran; 1,4-dioxane / 6 h / 20 °C

4.1: trifluoroacetic acid / 1,4-dioxane / 0.2 h / 160 °C / microwave

With Lawessons reagent; pyridine; hydrogen; trifluoroacetic acid; lithium hexamethyldisilazane; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; ethanol;

upstream raw materials:

7-methyl-4-(methylthio)-N-(3-(9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-yl)pyridin-2-yl)quinazolin-8-amine

4-chloro-aniline

7-methyl-quinazolin-4(3H)-one

6-bromo-7-methylquinazolin-4(3H)-one

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