5-{[(4-methoxyphenyl)methoxy]methyl}-5-[(phenylmethoxy)methyl]oxolan-3-one

Base Information

Chemical Name:5-{[(4-methoxyphenyl)methoxy]methyl}-5-[(phenylmethoxy)methyl]oxolan-3-one
CAS No.:249930-10-7
Molecular Formula:C₂₀H₂₂O₅
Molecular Weight:342.392
Hs Code.:

Synonyms:5-{[(4-methoxyphenyl)methoxy]methyl}-5-[(phenylmethoxy)methyl]oxolan-3-one

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Chemical Property of 5-{[(4-methoxyphenyl)methoxy]methyl}-5-[(phenylmethoxy)methyl]oxolan-3-one

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Technology Process of 5-{[(4-methoxyphenyl)methoxy]methyl}-5-[(phenylmethoxy)methyl]oxolan-3-one

There total 7 articles about 5-{[(4-methoxyphenyl)methoxy]methyl}-5-[(phenylmethoxy)methyl]oxolan-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 5-benzyloxymethyl-5-(4-methoxy-phenoxymethyl)-tetrahydro-furan-3-ol

: 249930-10-7
5-{[(4-methoxyphenyl)methoxy]methyl}-5-[(phenylmethoxy)methyl]oxolan-3-one

Guidance literature:: With pyridinium chloroformate; 4 A molecular sieve; In dichloromethane; at 20 ℃; for 4h;
DOI:10.1021/jm980713g

Reference yield:

: 2211-94-1,26744-15-0
2,3-epoxypropyl p-methoxyphenyl ether

: 249930-10-7
5-{[(4-methoxyphenyl)methoxy]methyl}-5-[(phenylmethoxy)methyl]oxolan-3-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: NaH / dimethylformamide / 0.5 h / 20 °C

1.2: 90 percent / dimethylformamide / 4 h / 80 °C

2.1: 92 percent / pyridinium chloroformate; 4A molecular sieve / CH₂Cl₂ / 24 h / 20 °C

3.1: 88 percent / tetrahydrofuran / 2 h / 20 °C

4.1: 3.44 g / 4-methylmorpholine N-oxide; OsO₄; H₂O / acetone; 2-methyl-propan-2-ol / 2 h / 20 °C

5.1: 2.74 g / TsCl; pyridine / 2 h / 20 °C

6.1: 50 percent / 4A molecular sieves; pyridinium chloroformate / CH₂Cl₂ / 4 h / 20 °C

With pyridine; osmium(VIII) oxide; pyridinium chloroformate; 4 A molecular sieve; water; sodium hydride; 4-methylmorpholine N-oxide; p-toluenesulfonyl chloride; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetone; tert-butyl alcohol; 1.1: Metallation / 1.2: Ring cleavage / 2.1: Oxidation / 3.1: Addition / 4.1: dihydroxylation / 5.1: Cyclization / 6.1: Oxidation;
DOI:10.1021/jm980713g

Reference yield:

: 213828-28-5
1-(benzyloxy)-3-(4-methoxyphenoxy)acetone

: 249930-10-7
5-{[(4-methoxyphenyl)methoxy]methyl}-5-[(phenylmethoxy)methyl]oxolan-3-one

Guidance literature:: Multi-step reaction with 4 steps

1: 88 percent / tetrahydrofuran / 2 h / 20 °C

2: 3.44 g / 4-methylmorpholine N-oxide; OsO₄; H₂O / acetone; 2-methyl-propan-2-ol / 2 h / 20 °C

3: 2.74 g / TsCl; pyridine / 2 h / 20 °C

4: 50 percent / 4A molecular sieves; pyridinium chloroformate / CH₂Cl₂ / 4 h / 20 °C

With pyridine; osmium(VIII) oxide; pyridinium chloroformate; 4 A molecular sieve; water; 4-methylmorpholine N-oxide; p-toluenesulfonyl chloride; In tetrahydrofuran; dichloromethane; acetone; tert-butyl alcohol; 1: Addition / 2: dihydroxylation / 3: Cyclization / 4: Oxidation;
DOI:10.1021/jm980713g