Technology Process of (Z)-methyl 2-{4-{[(4-methoxyphenyl)methoxy]methyl}-4-[(phenylmethoxy)methyl]-3-oxolanylidene}acetate
There total 8 articles about (Z)-methyl 2-{4-{[(4-methoxyphenyl)methoxy]methyl}-4-[(phenylmethoxy)methyl]-3-oxolanylidene}acetate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
trimethyl phosphonoacetate;
With
potassium tert-butylate;
In
tetrahydrofuran;
at 20 ℃;
for 1h;
5-{[(4-methoxyphenyl)methoxy]methyl}-5-[(phenylmethoxy)methyl]oxolan-3-one;
In
tetrahydrofuran;
for 10h;
Heating;
DOI:10.1021/jm980713g
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: NaH / dimethylformamide / 0.5 h / 20 °C
1.2: 90 percent / dimethylformamide / 4 h / 80 °C
2.1: 92 percent / pyridinium chloroformate; 4A molecular sieve / CH2Cl2 / 24 h / 20 °C
3.1: 88 percent / tetrahydrofuran / 2 h / 20 °C
4.1: 3.44 g / 4-methylmorpholine N-oxide; OsO4; H2O / acetone; 2-methyl-propan-2-ol / 2 h / 20 °C
5.1: 2.74 g / TsCl; pyridine / 2 h / 20 °C
6.1: 50 percent / 4A molecular sieves; pyridinium chloroformate / CH2Cl2 / 4 h / 20 °C
7.1: potassium tert-butoxide / tetrahydrofuran / 1 h / 20 °C
7.2: 35 percent / tetrahydrofuran / 10 h / Heating
With
pyridine; osmium(VIII) oxide; pyridinium chloroformate; 4 A molecular sieve; potassium tert-butylate; water; sodium hydride; 4-methylmorpholine N-oxide; p-toluenesulfonyl chloride;
In
tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetone; tert-butyl alcohol;
1.1: Metallation / 1.2: Ring cleavage / 2.1: Oxidation / 3.1: Addition / 4.1: dihydroxylation / 5.1: Cyclization / 6.1: Oxidation / 7.1: Metallation / 7.2: Condensation;
DOI:10.1021/jm980713g
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: 88 percent / tetrahydrofuran / 2 h / 20 °C
2.1: 3.44 g / 4-methylmorpholine N-oxide; OsO4; H2O / acetone; 2-methyl-propan-2-ol / 2 h / 20 °C
3.1: 2.74 g / TsCl; pyridine / 2 h / 20 °C
4.1: 50 percent / 4A molecular sieves; pyridinium chloroformate / CH2Cl2 / 4 h / 20 °C
5.1: potassium tert-butoxide / tetrahydrofuran / 1 h / 20 °C
5.2: 35 percent / tetrahydrofuran / 10 h / Heating
With
pyridine; osmium(VIII) oxide; pyridinium chloroformate; 4 A molecular sieve; potassium tert-butylate; water; 4-methylmorpholine N-oxide; p-toluenesulfonyl chloride;
In
tetrahydrofuran; dichloromethane; acetone; tert-butyl alcohol;
1.1: Addition / 2.1: dihydroxylation / 3.1: Cyclization / 4.1: Oxidation / 5.1: Metallation / 5.2: Condensation;
DOI:10.1021/jm980713g
