(S)-diethyl-(2-{4-[9-methoxy-4-(toluene-4-sulfonyl)-2,3,4,5-tetrahydrobenzo-[f][1,4]oxazepin-3-ylmethyl]-phenoxy}ethyl)amine

Base Information

Chemical Name:(S)-diethyl-(2-{4-[9-methoxy-4-(toluene-4-sulfonyl)-2,3,4,5-tetrahydrobenzo-[f][1,4]oxazepin-3-ylmethyl]-phenoxy}ethyl)amine
CAS No.:1208308-01-3
Molecular Formula:C₃₀H₃₈N₂O₅S
Molecular Weight:538.708
Hs Code.:

Synonyms:(S)-diethyl-(2-{4-[9-methoxy-4-(toluene-4-sulfonyl)-2,3,4,5-tetrahydrobenzo-[f][1,4]oxazepin-3-ylmethyl]-phenoxy}ethyl)amine

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Chemical Property of (S)-diethyl-(2-{4-[9-methoxy-4-(toluene-4-sulfonyl)-2,3,4,5-tetrahydrobenzo-[f][1,4]oxazepin-3-ylmethyl]-phenoxy}ethyl)amine

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Technology Process of (S)-diethyl-(2-{4-[9-methoxy-4-(toluene-4-sulfonyl)-2,3,4,5-tetrahydrobenzo-[f][1,4]oxazepin-3-ylmethyl]-phenoxy}ethyl)amine

There total 10 articles about (S)-diethyl-(2-{4-[9-methoxy-4-(toluene-4-sulfonyl)-2,3,4,5-tetrahydrobenzo-[f][1,4]oxazepin-3-ylmethyl]-phenoxy}ethyl)amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 1208307-91-8
(S)-4-((9-methoxy-4-tosyl-2,3,4,5-tetrahydrobenzo[f][1,4]oxazepin-3-yl)methyl)phenol

: 100-35-6
2-(diethylamino)ethyl chloride

: 1208308-01-3
(S)-diethyl-(2-{4-[9-methoxy-4-(toluene-4-sulfonyl)-2,3,4,5-tetrahydrobenzo-[f][1,4]oxazepin-3-ylmethyl]-phenoxy}ethyl)amine

Guidance literature:: With potassium carbonate; In acetone; at 70 ℃; for 3h;
DOI:10.1016/j.bmcl.2009.10.115

Reference yield:

: 1208307-84-9
(S)-N-(2-(benzyloxy)-3-methoxybenzyl)-N-(1-(4-(benzyloxy)phenyl)-3-hydroxypropan-2-yl)-4-methylbenzenesulfonamide

: 1208308-01-3
(S)-diethyl-(2-{4-[9-methoxy-4-(toluene-4-sulfonyl)-2,3,4,5-tetrahydrobenzo-[f][1,4]oxazepin-3-ylmethyl]-phenoxy}ethyl)amine

Guidance literature:: Multi-step reaction with 3 steps

1: palladium 10% on activated carbon; hydrogen / methanol / 2 h / 2585.81 Torr / Inert atmosphere

2: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 15 h / 0 - 20 °C / Inert atmosphere

3: potassium carbonate / acetone / 5 h / Reflux; Inert atmosphere

With palladium 10% on activated carbon; hydrogen; potassium carbonate; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; methanol; acetone; 2: |Mitsunobu Displacement;
DOI:10.1016/j.bmcl.2013.10.013

Reference yield:

: 1208307-81-6
methyl (S)-2-(N-(2-(benzyloxy)-3-methoxybenzyl)-4-methylphenylsulfonamido)-3-(4-(benzyloxy)phenyl)propanoate

: 1208308-01-3
(S)-diethyl-(2-{4-[9-methoxy-4-(toluene-4-sulfonyl)-2,3,4,5-tetrahydrobenzo-[f][1,4]oxazepin-3-ylmethyl]-phenoxy}ethyl)amine

Guidance literature:: Multi-step reaction with 4 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere

2: palladium 10% on activated carbon; hydrogen / methanol / 2 h / 2585.81 Torr / Inert atmosphere

3: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 15 h / 0 - 20 °C / Inert atmosphere

4: potassium carbonate / acetone / 5 h / Reflux; Inert atmosphere

With lithium aluminium tetrahydride; palladium 10% on activated carbon; hydrogen; potassium carbonate; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; methanol; acetone; 3: |Mitsunobu Displacement;
DOI:10.1016/j.bmcl.2013.10.013