Ethyl 2-cyano-4-oxo-2-(2-oxo-2-phenylethyl)-4-phenylbutanoate

Base Information

• Chemical Name: Ethyl 2-cyano-4-oxo-2-(2-oxo-2-phenylethyl)-4-phenylbutanoate
• CAS No.: 50459-71-7
• Molecular Formula: C₂₁H₁₉NO₄
• Molecular Weight: 349.386
• Mol file: 50459-71-7.mol

Synonyms:Ethyl 2-cyano-4-oxo-2-(2-oxo-2-phenylethyl)-4-phenylbutanoate

Chemical Property of Ethyl 2-cyano-4-oxo-2-(2-oxo-2-phenylethyl)-4-phenylbutanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Ethyl 2-cyano-4-oxo-2-(2-oxo-2-phenylethyl)-4-phenylbutanoate

There total 11 articles about Ethyl 2-cyano-4-oxo-2-(2-oxo-2-phenylethyl)-4-phenylbutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.6%

ethyl 2-cyanoacetate (105-56-6) + α-bromoacetophenone (70-11-1) → Ethyl 2-cyano-4-oxo-4-phenylbutanoate (22984-74-3) + Ethyl 2-cyano-4-oxo-2-(2-oxo-2-phenylethyl)-4-phenylbutanoate (50459-71-7)

Guidance literature:

ethyl 2-cyanoacetate; With potassium carbonate; at 40 - 45 ℃; for 0.75h;

α-bromoacetophenone; In acetone; at 40 - 45 ℃; for 1h;

DOI:10.1248/cpb.49.1406

Reference yield: 82.0%

ethyl 2-cyano-2-cyclohexylideneacetate (6802-76-2) + α-bromoacetophenone (70-11-1) → Ethyl 2-cyano-4-oxo-2-(2-oxo-2-phenylethyl)-4-phenylbutanoate (50459-71-7)

Guidance literature:

With potassium hydroxide; In water; N,N-dimethyl-formamide; at 20 ℃; for 2h; regioselective reaction;

DOI:10.1134/S1070428015120040

Reference yield: 80.0%

ethyl 2-cyanoacetate (105-56-6) + α-bromoacetophenone (70-11-1) → Ethyl 2-cyano-4-oxo-2-(2-oxo-2-phenylethyl)-4-phenylbutanoate (50459-71-7)

Guidance literature:

With potassium hydroxide; In ethanol; water; for 0.5h;

DOI:10.3390/molecules13123140

upstream raw materials:

sodium cyanoacetic acid ethyl ester

α-bromoacetophenone

ethanol

ethyl 2-cyanoacetate

Downstream raw materials:

4-oxo-2-phenacyl-4-phenyl-butyric acid

4-cyano-2,6-diphenyl-4-ethoxycarbonyl-4H-pyran

4-cyano-2,6-diphenyl-4-ethoxycarbonyl-4H-thiopyran

4-cyano-2,6-diphenyl-4-ethoxycarbonyl-1,4-dihydropyridine