N-(2-{(1S,4S)-5-[(2S)-2-amino-3,3-dimethylbutanoyl]-2,5-diazabicyclo[2.2.1]hept-2-yl}-2-oxoethyl)-2-chloro-5-(trifluoromethyl)benzenesulfonamide

Base Information

Chemical Name:N-(2-{(1S,4S)-5-[(2S)-2-amino-3,3-dimethylbutanoyl]-2,5-diazabicyclo[2.2.1]hept-2-yl}-2-oxoethyl)-2-chloro-5-(trifluoromethyl)benzenesulfonamide
CAS No.:1186643-71-9
Molecular Formula:C₁₉H₂₆Cl₂N₄O₄S
Molecular Weight:477.412
Hs Code.:

Synonyms:N-(2-{(1S,4S)-5-[(2S)-2-amino-3,3-dimethylbutanoyl]-2,5-diazabicyclo[2.2.1]hept-2-yl}-2-oxoethyl)-2-chloro-5-(trifluoromethyl)benzenesulfonamide

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Chemical Property of N-(2-{(1S,4S)-5-[(2S)-2-amino-3,3-dimethylbutanoyl]-2,5-diazabicyclo[2.2.1]hept-2-yl}-2-oxoethyl)-2-chloro-5-(trifluoromethyl)benzenesulfonamide

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Technology Process of N-(2-{(1S,4S)-5-[(2S)-2-amino-3,3-dimethylbutanoyl]-2,5-diazabicyclo[2.2.1]hept-2-yl}-2-oxoethyl)-2-chloro-5-(trifluoromethyl)benzenesulfonamide

There total 6 articles about N-(2-{(1S,4S)-5-[(2S)-2-amino-3,3-dimethylbutanoyl]-2,5-diazabicyclo[2.2.1]hept-2-yl}-2-oxoethyl)-2-chloro-5-(trifluoromethyl)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₄H₃₄Cl₂N₄O₆S

: 1186643-71-9
N-(2-{(1S,4S)-5-[(2S)-2-amino-3,3-dimethylbutanoyl]-2,5-diazabicyclo[2.2.1]hept-2-yl}-2-oxoethyl)-2-chloro-5-(trifluoromethyl)benzenesulfonamide

Guidance literature:: C₂₄H₃₄Cl₂N₄O₆S; With trifluoroacetic acid; In dichloromethane;

With ammonia; In methanol;

Reference yield:

: 113451-59-5,174823-32-6
(1S,4S)-2,5-Diaza-bicyclo[2.2.1]heptane-2-carboxylic acid tert-butyl ester

: 1186643-71-9
N-(2-{(1S,4S)-5-[(2S)-2-amino-3,3-dimethylbutanoyl]-2,5-diazabicyclo[2.2.1]hept-2-yl}-2-oxoethyl)-2-chloro-5-(trifluoromethyl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 6 steps

1: 4-methyl-morpholine; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide / dichloromethane / 24 h / 20 °C

2: trifluoroacetic acid / dichloromethane / 1 h

3: 4-methyl-morpholine; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide / dichloromethane / 24 h / 20 °C

4: ammonium formate / palladium 10% on activated carbon / ethanol / 20 °C

5: triethylamine / dichloromethane

6: trifluoroacetic acid / dichloromethane

With 4-methyl-morpholine; ammonium formate; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; trifluoroacetic acid; palladium 10% on activated carbon; In ethanol; dichloromethane;

Reference yield:

: 774610-01-4
1,1-dimethylethyl(1S,4S)-5-(N-{[benzyloxy]carbonyl}glycyl)-2,5-diazabicyclo[2.2.1]heptane-2-carboxylate

: 1186643-71-9
N-(2-{(1S,4S)-5-[(2S)-2-amino-3,3-dimethylbutanoyl]-2,5-diazabicyclo[2.2.1]hept-2-yl}-2-oxoethyl)-2-chloro-5-(trifluoromethyl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1: trifluoroacetic acid / dichloromethane / 1 h

2: 4-methyl-morpholine; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide / dichloromethane / 24 h / 20 °C

3: ammonium formate / palladium 10% on activated carbon / ethanol / 20 °C

4: triethylamine / dichloromethane

5: trifluoroacetic acid / dichloromethane

With 4-methyl-morpholine; ammonium formate; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; trifluoroacetic acid; palladium 10% on activated carbon; In ethanol; dichloromethane;