1,1-dimethylethyl [(1S)-2,2-dimethyl-1-({(1S,4S)-5-[({[(phenylmethyl)oxy]carbonyl}amino)acetyl]-2,5-diazabicyclo[2.2.1]hept-2-yl}carbonyl)propyl]carbamate

Base Information

• Chemical Name: 1,1-dimethylethyl [(1S)-2,2-dimethyl-1-({(1S,4S)-5-[({[(phenylmethyl)oxy]carbonyl}amino)acetyl]-2,5-diazabicyclo[2.2.1]hept-2-yl}carbonyl)propyl]carbamate
• CAS No.: 1186643-69-5
• Molecular Formula: C₂₆H₃₈N₄O₆
• Molecular Weight: 502.611

Synonyms:1,1-dimethylethyl [(1S)-2,2-dimethyl-1-({(1S,4S)-5-[({[(phenylmethyl)oxy]carbonyl}amino)acetyl]-2,5-diazabicyclo[2.2.1]hept-2-yl}carbonyl)propyl]carbamate

Chemical Property of 1,1-dimethylethyl [(1S)-2,2-dimethyl-1-({(1S,4S)-5-[({[(phenylmethyl)oxy]carbonyl}amino)acetyl]-2,5-diazabicyclo[2.2.1]hept-2-yl}carbonyl)propyl]carbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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Useful:

Technology Process of 1,1-dimethylethyl [(1S)-2,2-dimethyl-1-({(1S,4S)-5-[({[(phenylmethyl)oxy]carbonyl}amino)acetyl]-2,5-diazabicyclo[2.2.1]hept-2-yl}carbonyl)propyl]carbamate

There total 3 articles about 1,1-dimethylethyl [(1S)-2,2-dimethyl-1-({(1S,4S)-5-[({[(phenylmethyl)oxy]carbonyl}amino)acetyl]-2,5-diazabicyclo[2.2.1]hept-2-yl}carbonyl)propyl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-(Benzyloxycarbonyl)glycine (1138-80-3) → 1,1-dimethylethyl [(1S)-2,2-dimethyl-1-({(1S,4S)-5-[({[(phenylmethyl)oxy]carbonyl}amino)acetyl]-2,5-diazabicyclo[2.2.1]hept-2-yl}carbonyl)propyl]carbamate (1186643-69-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 4-methyl-morpholine; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide / dichloromethane / 24 h / 20 °C

2: trifluoroacetic acid / dichloromethane / 1 h

3: 4-methyl-morpholine; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide / dichloromethane / 24 h / 20 °C

With 4-methyl-morpholine; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; trifluoroacetic acid; In dichloromethane;

Reference yield:

1,1-dimethylethyl(1S,4S)-5-(N-{[benzyloxy]carbonyl}glycyl)-2,5-diazabicyclo[2.2.1]heptane-2-carboxylate (774610-01-4) → 1,1-dimethylethyl [(1S)-2,2-dimethyl-1-({(1S,4S)-5-[({[(phenylmethyl)oxy]carbonyl}amino)acetyl]-2,5-diazabicyclo[2.2.1]hept-2-yl}carbonyl)propyl]carbamate (1186643-69-5)

Guidance literature:

Multi-step reaction with 2 steps

1: trifluoroacetic acid / dichloromethane / 1 h

2: 4-methyl-morpholine; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide / dichloromethane / 24 h / 20 °C

With 4-methyl-morpholine; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; trifluoroacetic acid; In dichloromethane;

Reference yield:

(1S,4S)-2,5-Diaza-bicyclo[2.2.1]heptane-2-carboxylic acid tert-butyl ester (113451-59-5,174823-32-6) → 1,1-dimethylethyl [(1S)-2,2-dimethyl-1-({(1S,4S)-5-[({[(phenylmethyl)oxy]carbonyl}amino)acetyl]-2,5-diazabicyclo[2.2.1]hept-2-yl}carbonyl)propyl]carbamate (1186643-69-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 4-methyl-morpholine; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide / dichloromethane / 24 h / 20 °C

2: trifluoroacetic acid / dichloromethane / 1 h

3: 4-methyl-morpholine; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide / dichloromethane / 24 h / 20 °C

With 4-methyl-morpholine; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; trifluoroacetic acid; In dichloromethane;

upstream raw materials:

N-(Benzyloxycarbonyl)glycine

(1S,4S)-2,5-Diaza-bicyclo[2.2.1]heptane-2-carboxylic acid tert-butyl ester

1,1-dimethylethyl(1S,4S)-5-(N-{[benzyloxy]carbonyl}glycyl)-2,5-diazabicyclo[2.2.1]heptane-2-carboxylate

Downstream raw materials:

N-[(1S)-1-({(1S,4S)-5-[({[2-chloro-5-(trifluoromethyl)phenyl]sulfonyl}amino)acetyl]-2,5-diazabicyclo[2.2.1]hept-2-yl}carbonyl)-2,2-dimethylpropyl]-1-benzothiophene-2-carboxamide

N-(2-{(1 S,4S)-5-[(2S)-2-amino-3,3-dimethylbutanoyl]-2,5-diazabicyclo[2.2.1]hept-2-yl}-2-oxoethyl)-2-chloro-5-(trifluoromethyl)benzenesulfonamide

C₂₁H₃₀N₄O₄

N-[(1S)-1-({(1S,4S)-5-[({[5-chloro-2-(methyloxy)phenyl]sulfonyl}amino)acetyl]-2,5-diazabicyclo[2.2.1]hept-2-yl}carbonyl)-2,2-dimethylpropyl]-1H-indole-2-carboxamide

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