4,5-dibromo-2-(4-methoxyphenyl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazole

Base Information

Chemical Name:4,5-dibromo-2-(4-methoxyphenyl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazole
CAS No.:211615-68-8
Molecular Formula:C₁₆H₂₂Br₂N₂O₂Si
Molecular Weight:462.256
Hs Code.:

Synonyms:4,5-dibromo-2-(4-methoxyphenyl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazole

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Chemical Property of 4,5-dibromo-2-(4-methoxyphenyl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazole

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Technology Process of 4,5-dibromo-2-(4-methoxyphenyl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazole

There total 2 articles about 4,5-dibromo-2-(4-methoxyphenyl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 5720-07-0
4-methoxyphenylboronic acid

: 159590-01-9
2,4,5-tribromo-1-<<2-(trimethylsilyl)ethoxy>methyl>-1H-imidazole

: 211615-68-8
4,5-dibromo-2-(4-methoxyphenyl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazole

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In methanol; water; toluene; at 120 ℃; for 6.5h; regioselective reaction; Inert atmosphere;
DOI:10.1055/s-0032-1316906

Reference yield:

: 76513-69-4
(2-trimethylethylsilylethoxy)methyl chloride

: 211615-68-8
4,5-dibromo-2-(4-methoxyphenyl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazole

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

1.2: 20 °C / Inert atmosphere

2.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / methanol; toluene; water / 6.5 h / 120 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydride; potassium carbonate; In tetrahydrofuran; methanol; water; toluene; 2.1: |Suzuki-Miyaura Coupling;
DOI:10.1055/s-0032-1316906

Reference yield: 80.0%

: 211615-68-8
4,5-dibromo-2-(4-methoxyphenyl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazole

: 98-80-6
phenylboronic acid

: 1448032-62-9
2-(4-methoxyphenyl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-4,5-diphenyl-1H-imidazole

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In methanol; water; toluene; at 120 ℃; for 2.5h; Inert atmosphere;
DOI:10.1055/s-0032-1316906