2-(4-Methoxyphenyl)-4,5-diphenyl-1H-imidazole

Base Information

• Chemical Name: 2-(4-Methoxyphenyl)-4,5-diphenyl-1H-imidazole
• CAS No.: 1728-95-6
• Molecular Formula: C22H18 N2 O
• Molecular Weight: 326.398
• Hs Code.: 2933290090
• DSSTox Substance ID: DTXSID80938211
• Nikkaji Number: J900.600A
• Wikidata: Q82914475
• ChEMBL ID: CHEMBL390793
• Mol file: 1728-95-6.mol

Synonyms:2-(4-Methoxyphenyl)-4,5-diphenyl-1H-imidazole;1728-95-6;CCRIS 8669;1H-Imidazole, 2-(4-methoxyphenyl)-4,5-diphenyl-;SR-03000000711-1;C7H15NS.ClH;Oprea1_048302;Oprea1_526116;CHEMBL390793;cid_788012;SCHEMBL1132001;BDBM67490;DTXSID80938211;1-Piperidineethanethiol, hydrochloride;AKOS001068395;UPCMLD0ENAT5322389:001;LS-188249;Z57991284

Chemical Property of 2-(4-Methoxyphenyl)-4,5-diphenyl-1H-imidazole

Chemical Property:

• Vapor Pressure: 4.85E-11mmHg at 25°C
• Boiling Point: 536.5°Cat760mmHg
• Flash Point: 188.8°C
• PSA: 37.91000
• Density: 1.162g/cm³
• LogP: 5.41930
• XLogP3: 5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 4
• Exact Mass: 326.141913202
• Heavy Atom Count: 25
• Complexity: 395

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)C2=NC(=C(N2)C3=CC=CC=C3)C4=CC=CC=C4

Technology Process of 2-(4-Methoxyphenyl)-4,5-diphenyl-1H-imidazole

There total 17 articles about 2-(4-Methoxyphenyl)-4,5-diphenyl-1H-imidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

4-methoxy-benzaldehyde (123-11-5) + benzil (134-81-6) → 2-(4-methoxy-phenyl)-4,5-diphenyl-1H-imidazole (1728-95-6)

Guidance literature:

With hexaammonium heptamolybdate tetrahydrate; ammonium acetate; for 0.166667h; Neat (no solvent); Microwave irradiation;

DOI:10.1007/s12039-010-0051-6

Reference yield: 97.0%

4-methyl-benzaldehyde (104-87-0) + benzil (134-81-6) → 2-(4-methoxy-phenyl)-4,5-diphenyl-1H-imidazole (1728-95-6)

Guidance literature:

With ammonium acetate; In acetic acid; at 80 ℃; for 6h;

DOI:10.1016/j.jfluchem.2008.03.009

Reference yield: 97.0%

→ 2-(4-methoxy-phenyl)-4,5-diphenyl-1H-imidazole (1728-95-6)

Guidance literature:

With C₂₀H₂₆B₁₀Cl₃FeN₆; ammonium chloride; at 20 ℃; for 7h;

upstream raw materials:

4-methoxy-benzaldehyde

benzil

2-hydroxy-2-phenylacetophenone

4-methyl-benzaldehyde

Downstream raw materials:

4-hydroperoxy-2-(4-methoxyphenyl)-4,5-diphenyl-4-imidazole

[2-(4-methoxy-phenyl)-4,5-diphenyl-imidazol-1-yl]-acetic acid

2‐(2‐(4‐methoxyphenyl)‐4,5‐diphenyl‐1H‐imidazol‐1‐yl)acetohydrazide

1-(7-Ethoxycarbonylheptyl)2-(4-methoxyphenyl)-4,5-diphenylimidazole

Refernces

• 1、 Shaabani, Ahmad,Rahmati, Abbas,Aghaaliakbari, Behnaz,Safaei-Ghomi, Javad. "1,1,3,3-N,N,N′,N′-tetramethylguanidinium trifluoroacetate ionic liquid-promoted efficient one-pot synthesis of trisubstituted imidazoles". . p. 65 - 70. Retrieved 2006.
• 2、 Sanasi, Paul Douglas,Santhipriya,Ramesh,Kumar, M. Ravi,Swathi,Rao, K. Jaya. "Nano copper and cobalt ferrites as heterogeneous catalysts for the one-pot synthesis of 2,4,5-tri substituted imidazoles". . p. 1715 - 1720. Retrieved 2014.
• 3、 Wolkenberg, Scott E.,Wisnoski, David D.,Leister, William H.,Wang, Yi,Zhao, Zhijian,Lindsley, Craig W.. "Efficient synthesis of imidazoles from aldehydes and 1,2-diketones using microwave irradiation". . p. 1453 - 1456. Retrieved 2004.
• 4、 Amoozadeh, Ali,Kolvari, Eskandar,Sakhdari, Mahnaz. "Magnetic nanoparticle-supported sulfonic acid as a green catalyst for the one-pot synthesis of 2,4,5-trisubstituted imidazoles and 1,2,4,5-tetrasubstituted imidazoles under solvent-free conditions". . p. 71 - 78. Retrieved 2021/10/30.
• 5、 Indalkar, Krishna,Malge, Sanjay S.,Mali, Anil S.,Chaturbhuj, Ganesh U.. "Expeditious and Highly Efficient One-Pot Synthesis of Functionalized Imidazoles Catalyzed by Sulfated Polyborate". . p. 387 - 396. Retrieved 2021/07/26.