[6R-(6α,7β)]-3-[[[[5-(4-fluorophenyl)-5,8-dihydro-8-oxo-1,3-dioxolo[4,5-g]quinolin-7-yl]carbonyl]oxy]methyl]-8-oxo-7-[(phenoxyacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid sodium salt

Base Information

Chemical Name:[6R-(6α,7β)]-3-[[[[5-(4-fluorophenyl)-5,8-dihydro-8-oxo-1,3-dioxolo[4,5-g]quinolin-7-yl]carbonyl]oxy]methyl]-8-oxo-7-[(phenoxyacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid sodium salt
CAS No.:115699-51-9
Molecular Formula:C₃₃H₂₃FN₃O₁₀S*Na
Molecular Weight:695.614
Hs Code.:

[6R-(6α,7β)]-3-[[[[5-(4-fluorophenyl)-5,8-dihydro-8-oxo-1,3-dioxolo[4,5-g]quinolin-7-yl]carbonyl]oxy]methyl]-8-oxo-7-[(phenoxyacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid sodium salt

Synonyms:[6R-(6α,7β)]-3-[[[[5-(4-fluorophenyl)-5,8-dihydro-8-oxo-1,3-dioxolo[4,5-g]quinolin-7-yl]carbonyl]oxy]methyl]-8-oxo-7-[(phenoxyacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid sodium salt

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Chemical Property of [6R-(6α,7β)]-3-[[[[5-(4-fluorophenyl)-5,8-dihydro-8-oxo-1,3-dioxolo[4,5-g]quinolin-7-yl]carbonyl]oxy]methyl]-8-oxo-7-[(phenoxyacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid sodium salt

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Technology Process of [6R-(6α,7β)]-3-[[[[5-(4-fluorophenyl)-5,8-dihydro-8-oxo-1,3-dioxolo[4,5-g]quinolin-7-yl]carbonyl]oxy]methyl]-8-oxo-7-[(phenoxyacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid sodium salt

There total 4 articles about [6R-(6α,7β)]-3-[[[[5-(4-fluorophenyl)-5,8-dihydro-8-oxo-1,3-dioxolo[4,5-g]quinolin-7-yl]carbonyl]oxy]methyl]-8-oxo-7-[(phenoxyacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid sodium salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5-(4-fluorophenyl)-5,8-dihydro-8-oxo-1,3-dioxolo[4,5-g]quinoline-7-carboxylic acid potassium salt

: 115622-74-7
allyl 7β-(phenoxy)acetamido-3-(iodomethyl)-3-cephem-4-carboxylate

: 3375-31-3
palladium diacetate

: sodium 2-ethylhexanoic acid

: 115699-51-9
[6R-(6α,7β)]-3-[[[[5-(4-fluorophenyl)-5,8-dihydro-8-oxo-1,3-dioxolo[4,5-g]quinolin-7-yl]carbonyl]oxy]methyl]-8-oxo-7-[(phenoxyacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid sodium salt

Guidance literature:: With triethyl phosphite; In dichloromethane; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 115622-79-2
5-(4-Fluoro-phenyl)-8-oxo-5,8-dihydro-[1,3]dioxolo[4,5-g]quinoline-7-carboxylic acid (6R,7R)-2-allyloxycarbonyl-8-oxo-7-(2-phenoxy-acetylamino)-5-thia-1-aza-bicyclo[4.2.0]oct-2-en-3-ylmethyl ester

: 115699-51-9
(6R-trans)-3-<<<<5-(4-fluorophenyl)-5,8-dihydro-8-oxo-1,3-dioxolo<4,5-g>quinolin-7-yl>carbonyl>oxy>methyl>-8-oxo-7-<(phenoxyacetyl)amino>-5-thia-1-azabicyclo<4.2.0>oct-2-ene-2-carboxylic acid sodium salt

Guidance literature:: With palladium diacetate; triethyl phosphite; sodium 2-ethylhexanoic acid; In dichloromethane; ethyl acetate; for 0.5h;
DOI:10.1021/jm00163a013

Reference yield:

: 115622-74-7
(6R-trans)-3-(iodomethyl)-8-oxo-7-<(phenoxyacetyl)amino>-5-thia-1-azabicyclo<4.2.0>oct-2-ene-2-carboxylic acid allyl ester

: 115699-51-9
(6R-trans)-3-<<<<5-(4-fluorophenyl)-5,8-dihydro-8-oxo-1,3-dioxolo<4,5-g>quinolin-7-yl>carbonyl>oxy>methyl>-8-oxo-7-<(phenoxyacetyl)amino>-5-thia-1-azabicyclo<4.2.0>oct-2-ene-2-carboxylic acid sodium salt

Guidance literature:: Multi-step reaction with 2 steps

1: 36 percent / dimethylformamide / 6 h

2: triethyl phosphite, palladium(II) acetate, sodium 2-ethylhexanoate / ethyl acetate; CH₂Cl₂ / 0.5 h

With palladium diacetate; triethyl phosphite; sodium 2-ethylhexanoic acid; In dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm00163a013