Technology Process of 3-(4-fluorophenyl)-7-hydroxymethylindolizine-2-carboxylic acid ethyl ester
There total 6 articles about 3-(4-fluorophenyl)-7-hydroxymethylindolizine-2-carboxylic acid ethyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
water; potassium acetate;
bis-triphenylphosphine-palladium(II) chloride;
In
1-methyl-pyrrolidin-2-one;
at 100 ℃;
for 2h;
Inert atmosphere;
sealed tube;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 1H-imidazole / dichloromethane / 1 h / 0 - 20 °C
2: sodium hydrogencarbonate / acetonitrile / 3 h / 140 °C / Inert atmosphere; sealed tube
3: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 20 °C
4: water; potassium acetate / bis-triphenylphosphine-palladium(II) chloride / 1-methyl-pyrrolidin-2-one / 2 h / 100 °C / Inert atmosphere; sealed tube
With
1H-imidazole; tetrabutyl ammonium fluoride; water; potassium acetate; sodium hydrogencarbonate;
bis-triphenylphosphine-palladium(II) chloride;
In
tetrahydrofuran; 1-methyl-pyrrolidin-2-one; dichloromethane; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: triethylamine / bis[1,2-bis(diphenylphosphino)ferrocene]-palladium(0) / N,N-dimethyl-formamide; methanol / 75 °C / Inert atmosphere
2.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / -78 - 20 °C
2.2: 3 h / 0 - 20 °C
3.1: 1H-imidazole / dichloromethane / 1 h / 0 - 20 °C
4.1: sodium hydrogencarbonate / acetonitrile / 3 h / 140 °C / Inert atmosphere; sealed tube
5.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 20 °C
6.1: water; potassium acetate / bis-triphenylphosphine-palladium(II) chloride / 1-methyl-pyrrolidin-2-one / 2 h / 100 °C / Inert atmosphere; sealed tube
With
1H-imidazole; lithium aluminium tetrahydride; tetrabutyl ammonium fluoride; water; potassium acetate; sodium hydrogencarbonate; triethylamine;
bis-triphenylphosphine-palladium(II) chloride; bis[1,2-bis(diphenylphosphino)ferrocene]-palladium(0);
In
tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
