2-(3-(4-fluoro-3-methyl-phenyl)-5-phenyl-pyrazol-1-yl)-1-(4-(2-pyrimidinyl)-1-piperazinyl)-ethanone

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Chemical Name:2-(3-(4-fluoro-3-methyl-phenyl)-5-phenyl-pyrazol-1-yl)-1-(4-(2-pyrimidinyl)-1-piperazinyl)-ethanone
CAS No.:1439293-01-2
Molecular Formula:C₂₆H₂₅FN₆O
Molecular Weight:456.523
Hs Code.:

Synonyms:2-(3-(4-fluoro-3-methyl-phenyl)-5-phenyl-pyrazol-1-yl)-1-(4-(2-pyrimidinyl)-1-piperazinyl)-ethanone

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Chemical Property of 2-(3-(4-fluoro-3-methyl-phenyl)-5-phenyl-pyrazol-1-yl)-1-(4-(2-pyrimidinyl)-1-piperazinyl)-ethanone

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Technology Process of 2-(3-(4-fluoro-3-methyl-phenyl)-5-phenyl-pyrazol-1-yl)-1-(4-(2-pyrimidinyl)-1-piperazinyl)-ethanone

There total 6 articles about 2-(3-(4-fluoro-3-methyl-phenyl)-5-phenyl-pyrazol-1-yl)-1-(4-(2-pyrimidinyl)-1-piperazinyl)-ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 20980-22-7
N-(2-pyridinyl)piperazine

: 1439311-49-5
3-(4-fluoro-3-methyl-phenyl)-5-phenyl-pyrazol-1-yl acetic acid

: 1439293-01-2
2-(3-(4-fluoro-3-methyl-phenyl)-5-phenyl-pyrazol-1-yl)-1-(4-(2-pyrimidinyl)-1-piperazinyl)-ethanone

Guidance literature:: 3-(4-fluoro-3-methyl-phenyl)-5-phenyl-pyrazol-1-yl acetic acid; With N-ethyl-N,N-diisopropylamine; pentafluorophenol-tetramethyluronium hexafluorophosphate; In N,N-dimethyl-formamide; at 20 ℃; for 0.25h;

N-(2-pyridinyl)piperazine; In N,N-dimethyl-formamide; for 8h;

Reference yield:

: 98-86-2
acetophenone

: 1439293-01-2
2-(3-(4-fluoro-3-methyl-phenyl)-5-phenyl-pyrazol-1-yl)-1-(4-(2-pyrimidinyl)-1-piperazinyl)-ethanone

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium tert-butylate / tetrahydrofuran / 0.25 h / 20 °C

1.2: 3 h / 20 °C

2.1: hydrazine / tetrahydrofuran / 3 h / 75 °C

3.1: potassium carbonate / acetone / 10 h / Reflux

4.1: lithium hydroxide; water / 1,4-dioxane / 6 h / 89 °C

5.1: pentafluorophenol-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.25 h / 20 °C

5.2: 8 h

With potassium tert-butylate; water; potassium carbonate; N-ethyl-N,N-diisopropylamine; pentafluorophenol-tetramethyluronium hexafluorophosphate; lithium hydroxide; hydrazine; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide; acetone;

Reference yield:

: 1439306-15-6
3-(4-fluoro-3-methyl-phenyl)-5-phenyl-pyrazole

: 1439293-01-2
2-(3-(4-fluoro-3-methyl-phenyl)-5-phenyl-pyrazol-1-yl)-1-(4-(2-pyrimidinyl)-1-piperazinyl)-ethanone

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / acetone / 10 h / Reflux

2.1: lithium hydroxide; water / 1,4-dioxane / 6 h / 89 °C

3.1: pentafluorophenol-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.25 h / 20 °C

3.2: 8 h

With water; potassium carbonate; N-ethyl-N,N-diisopropylamine; pentafluorophenol-tetramethyluronium hexafluorophosphate; lithium hydroxide; In 1,4-dioxane; N,N-dimethyl-formamide; acetone;