diethyl 2-(4-nitrophenyl)-5-phenylisoxazolidine-3,3-dicarboxylate

Base Information

• Chemical Name: diethyl 2-(4-nitrophenyl)-5-phenylisoxazolidine-3,3-dicarboxylate
• CAS No.: 1629211-39-7
• Molecular Formula: C₂₁H₂₂N₂O₇
• Molecular Weight: 414.415
• Mol file: 1629211-39-7.mol

Synonyms:diethyl 2-(4-nitrophenyl)-5-phenylisoxazolidine-3,3-dicarboxylate

Chemical Property of diethyl 2-(4-nitrophenyl)-5-phenylisoxazolidine-3,3-dicarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of diethyl 2-(4-nitrophenyl)-5-phenylisoxazolidine-3,3-dicarboxylate

There total 2 articles about diethyl 2-(4-nitrophenyl)-5-phenylisoxazolidine-3,3-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-nitrosonitrobenzene (4485-08-9) + diethyl 2-phenylcyclopropane-1,1-dicarboxylate (3092-20-4) → diethyl 2-(4-nitrophenyl)-5-phenylisoxazolidine-3,3-dicarboxylate (1629211-39-7)

Guidance literature:

diethyl 2-phenylcyclopropane-1,1-dicarboxylate; With magnesium bromide; In 1,2-dichloro-ethane; at 20 ℃; for 0.416667h; Schlenk technique; Inert atmosphere;

4-nitrosonitrobenzene; In 1,2-dichloro-ethane; at 20 ℃; Schlenk technique; Inert atmosphere;

DOI:10.1002/anie.201400885

Reference yield: 70.0%

styrene (100-42-5,25038-60-2,25247-68-1,28213-80-1,28325-75-9,79637-11-9,9003-53-6) + 4-nitrosonitrobenzene (4485-08-9) + diethyl malonate (105-53-3) → diethyl 2-(4-nitrophenyl)-5-phenylisoxazolidine-3,3-dicarboxylate (1629211-39-7)

Guidance literature:

With N-Bromosuccinimide; 1,8-diazabicyclo[5.4.0]undec-7-ene; In 1,2-dichloro-ethane; at 50 ℃;

DOI:10.1021/acs.joc.0c02567

upstream raw materials:

4-nitrosonitrobenzene

diethyl 2-phenylcyclopropane-1,1-dicarboxylate

styrene

diethyl malonate