7-benzyl-1-cyano-4-hydroxy-8-oxo-7, 8-dihydro-[2,7]naphthyridine-3-carboxylic acidmethylamide

Base Information

Chemical Name:7-benzyl-1-cyano-4-hydroxy-8-oxo-7, 8-dihydro-[2,7]naphthyridine-3-carboxylic acidmethylamide
CAS No.:1392841-64-3
Molecular Formula:C₁₈H₁₄N₄O₃
Molecular Weight:334.334
Hs Code.:

Synonyms:7-benzyl-1-cyano-4-hydroxy-8-oxo-7, 8-dihydro-[2,7]naphthyridine-3-carboxylic acidmethylamide

Suppliers and Price of 7-benzyl-1-cyano-4-hydroxy-8-oxo-7, 8-dihydro-[2,7]naphthyridine-3-carboxylic acidmethylamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 7-benzyl-1-cyano-4-hydroxy-8-oxo-7, 8-dihydro-[2,7]naphthyridine-3-carboxylic acidmethylamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 7-benzyl-1-cyano-4-hydroxy-8-oxo-7, 8-dihydro-[2,7]naphthyridine-3-carboxylic acidmethylamide

There total 5 articles about 7-benzyl-1-cyano-4-hydroxy-8-oxo-7, 8-dihydro-[2,7]naphthyridine-3-carboxylic acidmethylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1392839-24-5
7-benzyl-1-cyano-4-hydroxy-8-oxo-7,8-dihydro-[2,7]naphthyridine-3-carboxylic acid methyl ester

: 74-89-5
methylamine

: 1392841-64-3
7-benzyl-1-cyano-4-hydroxy-8-oxo-7, 8-dihydro-[2,7]naphthyridine-3-carboxylic acidmethylamide

Guidance literature:: In tetrahydrofuran; ethanol; at 80 ℃; for 4h; Sealed tube;

Reference yield:

: 174740-67-1
dimethyl <2-(ethoxycarbonyl)ethylidene>malonate

: 1392841-64-3
7-benzyl-1-cyano-4-hydroxy-8-oxo-7, 8-dihydro-[2,7]naphthyridine-3-carboxylic acidmethylamide

Guidance literature:: Multi-step reaction with 9 steps

1.1: N,N-dimethyl-formamide / 3 h / 80 °C

2.1: ethanol / 5 h / Reflux

3.1: pyridine; lithium iodide / 1 h / Reflux

4.1: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 2.5 h

4.2: 16 h / 20 °C

4.3: 16 h / 20 °C

5.1: potassium carbonate; sodium iodide / N,N-dimethyl-formamide / 16 h / 20 °C

6.1: sodium methylate / methanol

6.2: pH 4

7.1: bis(2,4,6-trimethylpyridine)iodine(I) hexafluorophosphate / dichloromethane / 16 h / 20 °C

8.1: N,N-dimethyl-formamide / 0.13 h / Reflux; Inert atmosphere

9.1: ethanol; tetrahydrofuran / 4 h / 80 °C / Sealed tube

With pyridine; oxalyl dichloride; sodium methylate; potassium carbonate; sodium iodide; lithium iodide; bis(2,4,6-trimethylpyridine)iodine(I) hexafluorophosphate; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 174740-68-2
5-dimethylamino-3-ethoxycarbonyl-2-methoxycarbonyl-penta-2,4-dienoic acid methyl ester

: 1392841-64-3
7-benzyl-1-cyano-4-hydroxy-8-oxo-7, 8-dihydro-[2,7]naphthyridine-3-carboxylic acidmethylamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: ethanol / 5 h / Reflux

2.1: pyridine; lithium iodide / 1 h / Reflux

3.1: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 2.5 h

3.2: 16 h / 20 °C

3.3: 16 h / 20 °C

4.1: potassium carbonate; sodium iodide / N,N-dimethyl-formamide / 16 h / 20 °C

5.1: sodium methylate / methanol

5.2: pH 4

6.1: bis(2,4,6-trimethylpyridine)iodine(I) hexafluorophosphate / dichloromethane / 16 h / 20 °C

7.1: N,N-dimethyl-formamide / 0.13 h / Reflux; Inert atmosphere

8.1: ethanol; tetrahydrofuran / 4 h / 80 °C / Sealed tube

With pyridine; oxalyl dichloride; sodium methylate; potassium carbonate; sodium iodide; lithium iodide; bis(2,4,6-trimethylpyridine)iodine(I) hexafluorophosphate; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;