(5S,8S,11R,14S,17R,20S,22aS)-5,11-Dibenzyl-8,14-bis-(tert-butyl-dimethyl-silanyloxymethyl)-20-((S)-1-hydroxy-ethyl)-17-isopropyl-hexadecahydro-3a,6,9,12,15,18,21-heptaaza-cyclopentacyclohenicosene-4,7,10,13,16,19,22-heptaone

Base Information

Chemical Name:(5S,8S,11R,14S,17R,20S,22aS)-5,11-Dibenzyl-8,14-bis-(tert-butyl-dimethyl-silanyloxymethyl)-20-((S)-1-hydroxy-ethyl)-17-isopropyl-hexadecahydro-3a,6,9,12,15,18,21-heptaaza-cyclopentacyclohenicosene-4,7,10,13,16,19,22-heptaone
CAS No.:184296-07-9
Molecular Formula:C₅₀H₇₉N₇O₁₀Si₂
Molecular Weight:994.389
Hs Code.:

(5S,8S,11R,14S,17R,20S,22aS)-5,11-Dibenzyl-8,14-bis-(tert-butyl-dimethyl-silanyloxymethyl)-20-((S)-1-hydroxy-ethyl)-17-isopropyl-hexadecahydro-3a,6,9,12,15,18,21-heptaaza-cyclopentacyclohenicosene-4,7,10,13,16,19,22-heptaone

Synonyms:(5S,8S,11R,14S,17R,20S,22aS)-5,11-Dibenzyl-8,14-bis-(tert-butyl-dimethyl-silanyloxymethyl)-20-((S)-1-hydroxy-ethyl)-17-isopropyl-hexadecahydro-3a,6,9,12,15,18,21-heptaaza-cyclopentacyclohenicosene-4,7,10,13,16,19,22-heptaone

Suppliers and Price of (5S,8S,11R,14S,17R,20S,22aS)-5,11-Dibenzyl-8,14-bis-(tert-butyl-dimethyl-silanyloxymethyl)-20-((S)-1-hydroxy-ethyl)-17-isopropyl-hexadecahydro-3a,6,9,12,15,18,21-heptaaza-cyclopentacyclohenicosene-4,7,10,13,16,19,22-heptaone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (5S,8S,11R,14S,17R,20S,22aS)-5,11-Dibenzyl-8,14-bis-(tert-butyl-dimethyl-silanyloxymethyl)-20-((S)-1-hydroxy-ethyl)-17-isopropyl-hexadecahydro-3a,6,9,12,15,18,21-heptaaza-cyclopentacyclohenicosene-4,7,10,13,16,19,22-heptaone

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (5S,8S,11R,14S,17R,20S,22aS)-5,11-Dibenzyl-8,14-bis-(tert-butyl-dimethyl-silanyloxymethyl)-20-((S)-1-hydroxy-ethyl)-17-isopropyl-hexadecahydro-3a,6,9,12,15,18,21-heptaaza-cyclopentacyclohenicosene-4,7,10,13,16,19,22-heptaone

There total 25 articles about (5S,8S,11R,14S,17R,20S,22aS)-5,11-Dibenzyl-8,14-bis-(tert-butyl-dimethyl-silanyloxymethyl)-20-((S)-1-hydroxy-ethyl)-17-isopropyl-hexadecahydro-3a,6,9,12,15,18,21-heptaaza-cyclopentacyclohenicosene-4,7,10,13,16,19,22-heptaone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: C₅₀H₈₀N₇O₁₁Si₂^(1-)*Na⁽¹⁺⁾

: 184296-07-9
(5S,8S,11R,14S,17R,20S,22aS)-5,11-Dibenzyl-8,14-bis-(tert-butyl-dimethyl-silanyloxymethyl)-20-((S)-1-hydroxy-ethyl)-17-isopropyl-hexadecahydro-3a,6,9,12,15,18,21-heptaaza-cyclopentacyclohenicosene-4,7,10,13,16,19,22-heptaone

Guidance literature:: With pentafluorophenyl diphenyl-phosphinate; sodium hydrogencarbonate; In N,N-dimethyl-formamide; at 40 ℃; for 72h;
DOI:10.1021/ja962859f

Reference yield:

: 2448-45-5
Cbz-D-Phe

: 184296-07-9
(5S,8S,11R,14S,17R,20S,22aS)-5,11-Dibenzyl-8,14-bis-(tert-butyl-dimethyl-silanyloxymethyl)-20-((S)-1-hydroxy-ethyl)-17-isopropyl-hexadecahydro-3a,6,9,12,15,18,21-heptaaza-cyclopentacyclohenicosene-4,7,10,13,16,19,22-heptaone

Guidance literature:: Multi-step reaction with 13 steps

1: N-methylmorpholine / CH₂Cl₂ / 0.25 h / -15 °C

2: CH₂Cl₂ / 0 - 20 °C

3: imidazole / CH₂Cl₂

4: H₂ / Pd/C / methanol

5: CH₂Cl₂ / 0 - 20 °C

6: imidazole / CH₂Cl₂

7: H₂ / Pd/C / methanol / 2 h

8: CH₂Cl₂ / 1 h / 0 - 20 °C

9: 95 percent / aq. LiOH / tetrahydrofuran / 3 h / Ambient temperature

10: Et₃N, pentafluorophenyl diphenylphosphinate / CH₂Cl₂ / Ambient temperature

11: 92 percent / H₂ / Pd/C / methanol / 24 h

12: aq. NaOH / tetrahydrofuran; methanol / 4 h / Ambient temperature

13: 48 percent / NaHCO₃, pentafluorophenyl diphenylphosphinate / dimethylformamide / 72 h / 40 °C

With 4-methyl-morpholine; 1H-imidazole; lithium hydroxide; sodium hydroxide; pentafluorophenyl diphenyl-phosphinate; hydrogen; sodium hydrogencarbonate; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja962859f

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 184296-07-9
(5S,8S,11R,14S,17R,20S,22aS)-5,11-Dibenzyl-8,14-bis-(tert-butyl-dimethyl-silanyloxymethyl)-20-((S)-1-hydroxy-ethyl)-17-isopropyl-hexadecahydro-3a,6,9,12,15,18,21-heptaaza-cyclopentacyclohenicosene-4,7,10,13,16,19,22-heptaone

Guidance literature:: Multi-step reaction with 11 steps

1: imidazole / CH₂Cl₂

2: H₂ / Pd/C / methanol

3: CH₂Cl₂ / 0 - 20 °C

4: imidazole / CH₂Cl₂

5: H₂ / Pd/C / methanol / 2 h

6: CH₂Cl₂ / 1 h / 0 - 20 °C

7: 95 percent / aq. LiOH / tetrahydrofuran / 3 h / Ambient temperature

8: Et₃N, pentafluorophenyl diphenylphosphinate / CH₂Cl₂ / Ambient temperature

9: 92 percent / H₂ / Pd/C / methanol / 24 h

10: aq. NaOH / tetrahydrofuran; methanol / 4 h / Ambient temperature

11: 48 percent / NaHCO₃, pentafluorophenyl diphenylphosphinate / dimethylformamide / 72 h / 40 °C

With 1H-imidazole; lithium hydroxide; sodium hydroxide; pentafluorophenyl diphenyl-phosphinate; hydrogen; sodium hydrogencarbonate; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja962859f