(+/-)-1,1-dimethylethyl 4-{[3-(1-hydroxyethyl)phenyl]oxy}-1-piperidinecarboxylate

Base Information

Chemical Name:(+/-)-1,1-dimethylethyl 4-{[3-(1-hydroxyethyl)phenyl]oxy}-1-piperidinecarboxylate
CAS No.:960001-09-6
Molecular Formula:C₁₈H₂₇NO₄
Molecular Weight:321.417
Hs Code.:

Synonyms:(+/-)-1,1-dimethylethyl 4-{[3-(1-hydroxyethyl)phenyl]oxy}-1-piperidinecarboxylate

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Chemical Property of (+/-)-1,1-dimethylethyl 4-{[3-(1-hydroxyethyl)phenyl]oxy}-1-piperidinecarboxylate

Chemical Property:

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Technology Process of (+/-)-1,1-dimethylethyl 4-{[3-(1-hydroxyethyl)phenyl]oxy}-1-piperidinecarboxylate

There total 4 articles about (+/-)-1,1-dimethylethyl 4-{[3-(1-hydroxyethyl)phenyl]oxy}-1-piperidinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 858674-16-5
tert-butyl 4-(3-formylphenoxy)piperidine-1-carboxylate

: 676-58-4
methylmagnesium chloride

: 960001-09-6
(+/-)-1,1-dimethylethyl 4-{[3-(1-hydroxyethyl)phenyl]oxy}-1-piperidinecarboxylate

Guidance literature:: tert-butyl 4-(3-formylphenoxy)piperidine-1-carboxylate; methylmagnesium chloride; In tetrahydrofuran; diethyl ether; at -15 ℃; for 0.5h;

With water; ammonium chloride; In tetrahydrofuran; diethyl ether; at 20 ℃;

Reference yield:

: 960001-07-4
(3-hydroxy-phenyl)methyl 2,2-dimethyl-propanoate

: 960001-09-6
(+/-)-1,1-dimethylethyl 4-{[3-(1-hydroxyethyl)phenyl]oxy}-1-piperidinecarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: di-isopropyl azodicarboxylate; triphenylphosphine / dichloromethane / 18.08 h / 0 - 20 °C

2: lithium hydroxide; water / 1,4-dioxane / 3.5 h / 50 °C

3: manganese(IV) oxide / dichloromethane / 4 h

4: tetrahydrofuran; diethyl ether / 0.5 h / -15 °C

With manganese(IV) oxide; lithium hydroxide; di-isopropyl azodicarboxylate; water; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane; diethyl ether; dichloromethane;

Reference yield:

: 321337-39-7
tert-butyl 4-(3-(hydroxymethyl)phenoxy)piperidine-1-carboxylate

: 960001-09-6
(+/-)-1,1-dimethylethyl 4-{[3-(1-hydroxyethyl)phenyl]oxy}-1-piperidinecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: manganese(IV) oxide / dichloromethane / 4 h

2: tetrahydrofuran; diethyl ether / 0.5 h / -15 °C

With manganese(IV) oxide; In tetrahydrofuran; diethyl ether; dichloromethane;