3-(2'-tert-Butoxycarbonyl-biphenyl-4-ylmethyl)-5-(1-hydroxy-1-methyl-ethyl)-2-propyl-3H-imidazole-4-carboxylic acid benzyl ester

Base Information

Chemical Name:3-(2'-tert-Butoxycarbonyl-biphenyl-4-ylmethyl)-5-(1-hydroxy-1-methyl-ethyl)-2-propyl-3H-imidazole-4-carboxylic acid benzyl ester
CAS No.:172876-19-6
Molecular Formula:C₃₅H₄₀N₂O₅
Molecular Weight:568.713
Hs Code.:

Synonyms:3-(2'-tert-Butoxycarbonyl-biphenyl-4-ylmethyl)-5-(1-hydroxy-1-methyl-ethyl)-2-propyl-3H-imidazole-4-carboxylic acid benzyl ester

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Chemical Property of 3-(2'-tert-Butoxycarbonyl-biphenyl-4-ylmethyl)-5-(1-hydroxy-1-methyl-ethyl)-2-propyl-3H-imidazole-4-carboxylic acid benzyl ester

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Technology Process of 3-(2'-tert-Butoxycarbonyl-biphenyl-4-ylmethyl)-5-(1-hydroxy-1-methyl-ethyl)-2-propyl-3H-imidazole-4-carboxylic acid benzyl ester

There total 7 articles about 3-(2'-tert-Butoxycarbonyl-biphenyl-4-ylmethyl)-5-(1-hydroxy-1-methyl-ethyl)-2-propyl-3H-imidazole-4-carboxylic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 100-44-7
benzyl chloride

: 144690-41-5
1-[(2'-t-butoxycarbonylbiphenyl-4-yl)methyl]-4-(1-hydroxy-1-methylethyl)-2-propylimidazole-5-carboxylic acid

: 172876-19-6
3-(2'-tert-Butoxycarbonyl-biphenyl-4-ylmethyl)-5-(1-hydroxy-1-methyl-ethyl)-2-propyl-3H-imidazole-4-carboxylic acid benzyl ester

Guidance literature:: With potassium carbonate; In N,N-dimethyl acetamide; at 20 - 50 ℃; for 3h;
DOI:10.1021/jm950450f

Reference yield:

: 58954-23-7
2-propyl-1H-imidazole-4,5-dicarboxylic acid

: 172876-19-6
3-(2'-tert-Butoxycarbonyl-biphenyl-4-ylmethyl)-5-(1-hydroxy-1-methyl-ethyl)-2-propyl-3H-imidazole-4-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 86 percent / HCl / Ambient temperature

2: 95 percent / diethyl ether; CH₂Cl₂ / 1 h / 10 - 15 °C

3: 1.) t-BuOK / 1.) DMA, 0 deg C, 10 min, 2.) DMA, RT, 1 h

4: 100 percent / LiOH*H₂O / dioxane; H₂O / 20 h / Ambient temperature

5: 96 percent / K₂CO₃ / N,N-dimethyl-acetamide / 3 h / 20 - 50 °C

With hydrogenchloride; lithium hydroxide; potassium tert-butylate; potassium carbonate; In 1,4-dioxane; diethyl ether; dichloromethane; N,N-dimethyl acetamide; water;
DOI:10.1021/jm950450f

Reference yield:

: 114772-40-6
4'-bromomethyl-biphenyl-2-carboxylic acid tert-butyl ester

: 172876-19-6
3-(2'-tert-Butoxycarbonyl-biphenyl-4-ylmethyl)-5-(1-hydroxy-1-methyl-ethyl)-2-propyl-3H-imidazole-4-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) t-BuOK / 1.) DMA, 0 deg C, 10 min, 2.) DMA, RT, 1 h

2: 100 percent / LiOH*H₂O / dioxane; H₂O / 20 h / Ambient temperature

3: 96 percent / K₂CO₃ / N,N-dimethyl-acetamide / 3 h / 20 - 50 °C

With lithium hydroxide; potassium tert-butylate; potassium carbonate; In 1,4-dioxane; N,N-dimethyl acetamide; water;
DOI:10.1021/jm950450f