3-[({[(4-hydroxy-3,5-di-tert-butylphenyl)thio]acetyl}amino)sulfonyl]-4-chlorobenzoic acid

Base Information

Chemical Name:3-[({[(4-hydroxy-3,5-di-tert-butylphenyl)thio]acetyl}amino)sulfonyl]-4-chlorobenzoic acid
CAS No.:173457-18-6
Molecular Formula:C₂₃H₂₈ClNO₆S₂
Molecular Weight:514.063
Hs Code.:

Synonyms:3-[({[(4-hydroxy-3,5-di-tert-butylphenyl)thio]acetyl}amino)sulfonyl]-4-chlorobenzoic acid

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Chemical Property of 3-[({[(4-hydroxy-3,5-di-tert-butylphenyl)thio]acetyl}amino)sulfonyl]-4-chlorobenzoic acid

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Technology Process of 3-[({[(4-hydroxy-3,5-di-tert-butylphenyl)thio]acetyl}amino)sulfonyl]-4-chlorobenzoic acid

There total 4 articles about 3-[({[(4-hydroxy-3,5-di-tert-butylphenyl)thio]acetyl}amino)sulfonyl]-4-chlorobenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 173457-17-5
ethyl 3-[({[(4-hydroxy-3,5-di-tert-butylphenyl)thio]acetyl}amino)sulfonyl]-4-chlorobenzoate

: 173457-18-6
3-[({[(4-hydroxy-3,5-di-tert-butylphenyl)thio]acetyl}amino)sulfonyl]-4-chlorobenzoic acid

Guidance literature:: With sodium hydroxide; In ethanol; at 60 ℃; for 20h;
DOI:10.1021/jm960772z

Reference yield:

: 950-59-4
4-hydroxy-3,5-di-tert-butylthiophenol

: 173457-18-6
3-[({[(4-hydroxy-3,5-di-tert-butylphenyl)thio]acetyl}amino)sulfonyl]-4-chlorobenzoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 71 percent / K₂CO₃

2: 46 percent / TFA / CH₂Cl₂

3: DMAP, DCC / dimethylformamide / 48 h / Ambient temperature

4: aq. NaOH / ethanol / 20 h / 60 °C

With dmap; sodium hydroxide; potassium carbonate; dicyclohexyl-carbodiimide; trifluoroacetic acid; In ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm960772z

Reference yield:

: 61151-53-9
4-hydroxy-3,5-di-tert-butylphenylmercaptoacetic acid

: 173457-18-6
3-[({[(4-hydroxy-3,5-di-tert-butylphenyl)thio]acetyl}amino)sulfonyl]-4-chlorobenzoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: DMAP, DCC / dimethylformamide / 48 h / Ambient temperature

2: aq. NaOH / ethanol / 20 h / 60 °C

With dmap; sodium hydroxide; dicyclohexyl-carbodiimide; In ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm960772z