methyl 3α,12α-bis(2-((7-benzyloxy)naphthyloxy)acetyloxy)-5β-cholan-24-oate

Base Information

Chemical Name:methyl 3α,12α-bis(2-((7-benzyloxy)naphthyloxy)acetyloxy)-5β-cholan-24-oate
CAS No.:317806-81-8
Molecular Formula:C₆₃H₇₀O₁₀
Molecular Weight:987.243
Hs Code.:

Synonyms:methyl 3α,12α-bis(2-((7-benzyloxy)naphthyloxy)acetyloxy)-5β-cholan-24-oate

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Chemical Property of methyl 3α,12α-bis(2-((7-benzyloxy)naphthyloxy)acetyloxy)-5β-cholan-24-oate

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Technology Process of methyl 3α,12α-bis(2-((7-benzyloxy)naphthyloxy)acetyloxy)-5β-cholan-24-oate

There total 5 articles about methyl 3α,12α-bis(2-((7-benzyloxy)naphthyloxy)acetyloxy)-5β-cholan-24-oate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.8%

: 3245-38-3
methyl deoxycholate

: (7-benzyloxy-naphthalen-2-yloxy)-acetyl chloride

: 317806-81-8
methyl 3α,12α-bis(2-((7-benzyloxy)naphthyloxy)acetyloxy)-5β-cholan-24-oate

Guidance literature:: With calcium hydride; N-benzyl-N,N,N-triethylammonium chloride; In toluene; for 18h; Heating;
DOI:10.1021/jo000703z

Reference yield:

: 582-17-2
2,7-Dihydroxynaphthalene

: 317806-81-8
methyl 3α,12α-bis(2-((7-benzyloxy)naphthyloxy)acetyloxy)-5β-cholan-24-oate

Guidance literature:: Multi-step reaction with 5 steps

1: K₂CO₃ / dimethylformamide

2: 96 percent / K₂CO₃ / acetone / 22 h / Heating

3: NaOH / methanol; H₂O / 19 h / Heating

4: oxalyly chloride; DMF / benzene / 2.5 h / 45 °C

5: 83.8 percent / CaH₂; benzyltriethylammonium chloride / toluene / 18 h / Heating

With sodium hydroxide; calcium hydride; oxalyl dichloride; N-benzyl-N,N,N-triethylammonium chloride; potassium carbonate; N,N-dimethyl-formamide; In methanol; water; N,N-dimethyl-formamide; acetone; toluene; benzene; 5: Oppenauer esterification;
DOI:10.1021/jo000703z

Reference yield:

: 118495-07-1
7-(benzyloxy)-2-naphthol

: 317806-81-8
methyl 3α,12α-bis(2-((7-benzyloxy)naphthyloxy)acetyloxy)-5β-cholan-24-oate

Guidance literature:: Multi-step reaction with 4 steps

1: 96 percent / K₂CO₃ / acetone / 22 h / Heating

2: NaOH / methanol; H₂O / 19 h / Heating

3: oxalyly chloride; DMF / benzene / 2.5 h / 45 °C

4: 83.8 percent / CaH₂; benzyltriethylammonium chloride / toluene / 18 h / Heating

With sodium hydroxide; calcium hydride; oxalyl dichloride; N-benzyl-N,N,N-triethylammonium chloride; potassium carbonate; N,N-dimethyl-formamide; In methanol; water; acetone; toluene; benzene; 4: Oppenauer esterification;
DOI:10.1021/jo000703z