Benzoic acid (S)-2-acetylsulfanyl-4-benzyloxy-4-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-3,3-difluoro-butyl ester

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Chemical Name:Benzoic acid (S)-2-acetylsulfanyl-4-benzyloxy-4-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-3,3-difluoro-butyl ester
CAS No.:921202-63-3
Molecular Formula:C₂₅H₂₈F₂O₆S
Molecular Weight:494.557
Hs Code.:

Synonyms:Benzoic acid (S)-2-acetylsulfanyl-4-benzyloxy-4-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-3,3-difluoro-butyl ester

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Chemical Property of Benzoic acid (S)-2-acetylsulfanyl-4-benzyloxy-4-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-3,3-difluoro-butyl ester

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Technology Process of Benzoic acid (S)-2-acetylsulfanyl-4-benzyloxy-4-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-3,3-difluoro-butyl ester

There total 2 articles about Benzoic acid (S)-2-acetylsulfanyl-4-benzyloxy-4-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-3,3-difluoro-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: Benzoic acid (R)-4-benzyloxy-4-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-3,3-difluoro-2-trifluoromethanesulfonyloxy-butyl ester

: 507-09-5
tiolacetic acid

: 921202-63-3
Benzoic acid (S)-2-acetylsulfanyl-4-benzyloxy-4-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-3,3-difluoro-butyl ester

Guidance literature:: With cesium fluoride; In N,N-dimethyl-formamide; at 20 ℃; for 13h;
DOI:10.1021/ol062576k

Reference yield:

: 921202-48-4
(2R,5R)-4-O-benzyl-1-O-benzoyl-3,3-difluoro-5,6-O-isopropylidenehexane-1,2,4,5,6-pentol

: 921202-63-3
Benzoic acid (S)-2-acetylsulfanyl-4-benzyloxy-4-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-3,3-difluoro-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / CH₂Cl₂ / -40 - -20 °C

2: 87 percent / CsF / dimethylformamide / 13 h / 20 °C

With pyridine; cesium fluoride; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ol062576k

Reference yield: 64.0%

: 921202-63-3
Benzoic acid (S)-2-acetylsulfanyl-4-benzyloxy-4-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-3,3-difluoro-butyl ester

: 2-O-benzyl-5-O-benzoyl-3-deoxy-3,3-difluoro-4-thio-L-xylofuranose

Guidance literature:: Benzoic acid (S)-2-acetylsulfanyl-4-benzyloxy-4-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-3,3-difluoro-butyl ester; With trifluoroacetic acid; In tetrahydrofuran; water; for 1h;

With sodium periodate; In methanol; water; for 1.5h;

With hydrogenchloride; In methanol;
DOI:10.1021/ol062576k