2-(5-((tert-Butoxycarbonyl)amino)-6-oxo-2-phenylpyrimidin-1(6H)-yl)acetic acid

Base Information

• Chemical Name: 2-(5-((tert-Butoxycarbonyl)amino)-6-oxo-2-phenylpyrimidin-1(6H)-yl)acetic acid
• CAS No.: 184710-54-1
• Molecular Formula: C₁₇H₁₉N₃O₅
• Molecular Weight: 345.355
• Hs Code.: 2933599090
• DSSTox Substance ID: DTXSID20698266
• Wikidata: Q82628430
• Mol file: 184710-54-1.mol

Synonyms:184710-54-1;2-(5-((tert-Butoxycarbonyl)amino)-6-oxo-2-phenylpyrimidin-1(6H)-yl)acetic acid;2-(5-(TERT-BUTOXYCARBONYLAMINO)-6-OXO-2-PHENYLPYRIMIDIN-1(6H)-YL)ACETIC ACID;2-[5-[(2-methylpropan-2-yl)oxycarbonylamino]-6-oxo-2-phenylpyrimidin-1-yl]acetic acid;SCHEMBL7953847;DTXSID20698266;PTAQXLKRPCHZQW-UHFFFAOYSA-N;SB58400;2-(5-((tert-Butoxycarbonyl)amino)-6-oxo-2-phenylpyrimidin-1(6H)-yl)aceticacid;FT-0689714;{5-[(tert-Butoxycarbonyl)amino]-6-oxo-2-phenylpyrimidin-1(6H)-yl}acetic acid;5-[[(1,1-dimethylethoxy)carbonyl]amino]-6-oxo-2-phenyl-1(6H)-Pyrimidineacetic acid

Chemical Property of 2-(5-((tert-Butoxycarbonyl)amino)-6-oxo-2-phenylpyrimidin-1(6H)-yl)acetic acid

Chemical Property:

• PSA: 110.52000
• LogP: 2.41490
• Storage Temp.: 2-8°C
• XLogP3: 1.5
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 6
• Exact Mass: 345.13247072
• Heavy Atom Count: 25
• Complexity: 612

Purity/Quality:

2-(5-((tert-Butoxycarbonyl)amino)-6-oxo-2-phenylpyrimidin-1(6H)-yl)acetic acid 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)(C)OC(=O)NC1=CN=C(N(C1=O)CC(=O)O)C2=CC=CC=C2

Technology Process of 2-(5-((tert-Butoxycarbonyl)amino)-6-oxo-2-phenylpyrimidin-1(6H)-yl)acetic acid

There total 4 articles about 2-(5-((tert-Butoxycarbonyl)amino)-6-oxo-2-phenylpyrimidin-1(6H)-yl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl 2-[5-(tert-butoxycarbonylamino)-6-oxo-2-phenylhydropyrimidinyl]acetate (356533-99-8) → 2-[5-(tert-butoxycarbonylamino)-6-oxo-2-phenylhydropyrimidinyl]acetic acid (184710-54-1)

Guidance literature:

With sodium hydroxide; In methanol; at 20 ℃; for 2h;

DOI:10.1016/S0968-0896(01)00007-4

Reference yield:

5-benzyloxycarbonylamino-6-oxo-2-phenyl-1,6-dihydropyrimidin-1-ylmethylcarboxylic acid (148747-59-5) → 2-[5-(tert-butoxycarbonylamino)-6-oxo-2-phenylhydropyrimidinyl]acetic acid (184710-54-1)

Guidance literature:

Multi-step reaction with 4 steps

1: 1.83 g / diethyl ether; methanol / 0 °C

2: 95 percent / hydrogen; HCl / Pd-C / ethyl acetate; methanol / 2 h / 20 °C

3: 93 percent / tetrahydrofuran / 120 h / Heating

4: 1.07 g / sodium hydroxide / methanol / 2 h / 20 °C

With hydrogenchloride; sodium hydroxide; hydrogen; palladium on activated charcoal; In tetrahydrofuran; methanol; diethyl ether; ethyl acetate;

DOI:10.1016/S0968-0896(01)00007-4

Reference yield:

(5-Benzyloxycarbonylamino-6-oxo-2-phenyl-6H-pyrimidin-1-yl)-acetic acid methyl ester → 2-[5-(tert-butoxycarbonylamino)-6-oxo-2-phenylhydropyrimidinyl]acetic acid (184710-54-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 95 percent / hydrogen; HCl / Pd-C / ethyl acetate; methanol / 2 h / 20 °C

2: 93 percent / tetrahydrofuran / 120 h / Heating

3: 1.07 g / sodium hydroxide / methanol / 2 h / 20 °C

With hydrogenchloride; sodium hydroxide; hydrogen; palladium on activated charcoal; In tetrahydrofuran; methanol; ethyl acetate;

DOI:10.1016/S0968-0896(01)00007-4

upstream raw materials:

methyl 2-[5-(tert-butoxycarbonylamino)-6-oxo-2-phenylhydropyrimidinyl]acetate

5-benzyloxycarbonylamino-6-oxo-2-phenyl-1,6-dihydropyrimidin-1-ylmethylcarboxylic acid

(5-Amino-6-oxo-2-phenyl-6H-pyrimidin-1-yl)-acetic acid methyl ester

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