5-[[(1,1-dimethylethoxy)carbonyl]amino]-6-oxo-2-phenyl-1(6H)-Pyrimidineacetic acid methyl ester

Base Information

Chemical Name:5-[[(1,1-dimethylethoxy)carbonyl]amino]-6-oxo-2-phenyl-1(6H)-Pyrimidineacetic acid methyl ester
CAS No.:356533-99-8
Molecular Formula:C₁₈H₂₁N₃O₅
Molecular Weight:359.382
Hs Code.:

Synonyms:5-[[(1,1-dimethylethoxy)carbonyl]amino]-6-oxo-2-phenyl-1(6H)-Pyrimidineacetic acid methyl ester

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Chemical Property of 5-[[(1,1-dimethylethoxy)carbonyl]amino]-6-oxo-2-phenyl-1(6H)-Pyrimidineacetic acid methyl ester

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Technology Process of 5-[[(1,1-dimethylethoxy)carbonyl]amino]-6-oxo-2-phenyl-1(6H)-Pyrimidineacetic acid methyl ester

There total 3 articles about 5-[[(1,1-dimethylethoxy)carbonyl]amino]-6-oxo-2-phenyl-1(6H)-Pyrimidineacetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 873673-51-9
(5-Amino-6-oxo-2-phenyl-6H-pyrimidin-1-yl)-acetic acid methyl ester

: 356533-99-8
methyl 2-[5-(tert-butoxycarbonylamino)-6-oxo-2-phenylhydropyrimidinyl]acetate

Guidance literature:: In tetrahydrofuran; for 120h; Heating;
DOI:10.1016/S0968-0896(01)00007-4

Reference yield:

: 148747-59-5
5-benzyloxycarbonylamino-6-oxo-2-phenyl-1,6-dihydropyrimidin-1-ylmethylcarboxylic acid

: 356533-99-8
methyl 2-[5-(tert-butoxycarbonylamino)-6-oxo-2-phenylhydropyrimidinyl]acetate

Guidance literature:: Multi-step reaction with 3 steps

1: 1.83 g / diethyl ether; methanol / 0 °C

2: 95 percent / hydrogen; HCl / Pd-C / ethyl acetate; methanol / 2 h / 20 °C

3: 93 percent / tetrahydrofuran / 120 h / Heating

With hydrogenchloride; hydrogen; palladium on activated charcoal; In tetrahydrofuran; methanol; diethyl ether; ethyl acetate;
DOI:10.1016/S0968-0896(01)00007-4

Reference yield:

: (5-Benzyloxycarbonylamino-6-oxo-2-phenyl-6H-pyrimidin-1-yl)-acetic acid methyl ester

: 356533-99-8
methyl 2-[5-(tert-butoxycarbonylamino)-6-oxo-2-phenylhydropyrimidinyl]acetate

Guidance literature:: Multi-step reaction with 2 steps

1: 95 percent / hydrogen; HCl / Pd-C / ethyl acetate; methanol / 2 h / 20 °C

2: 93 percent / tetrahydrofuran / 120 h / Heating

With hydrogenchloride; hydrogen; palladium on activated charcoal; In tetrahydrofuran; methanol; ethyl acetate;
DOI:10.1016/S0968-0896(01)00007-4