3-[1-(2,3-difluorobenzyl)-6-methyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl]-7,7-dimethyl-5,7-dihydro-6H-pyrrolo[2,3-e][1,2,4]triazin-6-one

Base Information

Chemical Name:3-[1-(2,3-difluorobenzyl)-6-methyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl]-7,7-dimethyl-5,7-dihydro-6H-pyrrolo[2,3-e][1,2,4]triazin-6-one
CAS No.:1446712-48-6
Molecular Formula:C₂₀H₁₆F₂N₈O
Molecular Weight:422.397
Hs Code.:

Synonyms:3-[1-(2,3-difluorobenzyl)-6-methyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl]-7,7-dimethyl-5,7-dihydro-6H-pyrrolo[2,3-e][1,2,4]triazin-6-one

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Chemical Property of 3-[1-(2,3-difluorobenzyl)-6-methyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl]-7,7-dimethyl-5,7-dihydro-6H-pyrrolo[2,3-e][1,2,4]triazin-6-one

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Technology Process of 3-[1-(2,3-difluorobenzyl)-6-methyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl]-7,7-dimethyl-5,7-dihydro-6H-pyrrolo[2,3-e][1,2,4]triazin-6-one

There total 8 articles about 3-[1-(2,3-difluorobenzyl)-6-methyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl]-7,7-dimethyl-5,7-dihydro-6H-pyrrolo[2,3-e][1,2,4]triazin-6-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1446712-63-5
methyl 2-{3-[1-(2,3-difluorobenzyl)-6-methyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl]-5-hydroxy-1,2,4-triazin-6-yl}-2-methylpropanoate

: 1446712-48-6
3-[1-(2,3-difluorobenzyl)-6-methyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl]-7,7-dimethyl-5,7-dihydro-6H-pyrrolo[2,3-e][1,2,4]triazin-6-one

Guidance literature:: methyl 2-{3-[1-(2,3-difluorobenzyl)-6-methyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl]-5-hydroxy-1,2,4-triazin-6-yl}-2-methylpropanoate; With trichlorophosphate; at 20 ℃; for 2.5h;

With ammonium hydroxide; In acetonitrile; at 20 ℃; for 1h; Cooling with ice;

Reference yield:

: 1446712-60-2
1-(2,3-difluorobenzyl)-6-methyl-1H-pyrazolo[3,4-d]pyrimidine-3-carboximidamide

: 1446712-48-6
3-[1-(2,3-difluorobenzyl)-6-methyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl]-7,7-dimethyl-5,7-dihydro-6H-pyrrolo[2,3-e][1,2,4]triazin-6-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine; hydrazine hydrate / ethanol / 72 h / 0 - 20 °C / Inert atmosphere

2.1: ethanol / Reflux

3.1: trichlorophosphate / 2.5 h / 20 °C

3.2: 1 h / 20 °C / Cooling with ice

With hydrazine hydrate; triethylamine; trichlorophosphate; In ethanol;

Reference yield:

: 1446712-58-8
1-(2,3-difluorobenzyl)-3-iodo-6-methyl-1H-pyrazolo[3,4-d]pyrimidine

: 1446712-48-6
3-[1-(2,3-difluorobenzyl)-6-methyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl]-7,7-dimethyl-5,7-dihydro-6H-pyrrolo[2,3-e][1,2,4]triazin-6-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: dimethyl sulfoxide / 2 h / 150 °C

2.1: sodium methylate / methanol / 1 h / 20 °C / Inert atmosphere

2.2: 2 h / Inert atmosphere; Reflux

3.1: triethylamine; hydrazine hydrate / ethanol / 72 h / 0 - 20 °C / Inert atmosphere

4.1: ethanol / Reflux

5.1: trichlorophosphate / 2.5 h / 20 °C

5.2: 1 h / 20 °C / Cooling with ice

With sodium methylate; hydrazine hydrate; triethylamine; trichlorophosphate; In methanol; ethanol; dimethyl sulfoxide;