tert-butyl ((2S,3R)-3-(tert-butoxy)-1-oxo-1-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzenesulfonamido)butan-2-yl)carbamate

Base Information

• Chemical Name: tert-butyl ((2S,3R)-3-(tert-butoxy)-1-oxo-1-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzenesulfonamido)butan-2-yl)carbamate
• CAS No.: 1422970-00-0
• Molecular Formula: C₂₅H₄₁BN₂O₈S
• Molecular Weight: 540.486
• Mol file: 1422970-00-0.mol

Synonyms:tert-butyl ((2S,3R)-3-(tert-butoxy)-1-oxo-1-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzenesulfonamido)butan-2-yl)carbamate

Chemical Property of tert-butyl ((2S,3R)-3-(tert-butoxy)-1-oxo-1-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzenesulfonamido)butan-2-yl)carbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl ((2S,3R)-3-(tert-butoxy)-1-oxo-1-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzenesulfonamido)butan-2-yl)carbamate

There total 1 articles about tert-butyl ((2S,3R)-3-(tert-butoxy)-1-oxo-1-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzenesulfonamido)butan-2-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzene-1-sulfonamide (486422-08-6) + (2S,3R)-3-tert-butoxy-2-tert-butoxycarbonylaminobutyric acid (13734-40-2) → tert-butyl ((2S,3R)-3-(tert-butoxy)-1-oxo-1-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzenesulfonamido)butan-2-yl)carbamate (1422970-00-0)

Guidance literature:

(2S,3R)-3-tert-butoxy-2-tert-butoxycarbonylaminobutyric acid; With 1,8-diazabicyclo[5.4.0]undec-7-ene; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 0.5h;

3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzene-1-sulfonamide; With 1-hydroxy-7-aza-benzotriazole; In dichloromethane; for 2h;

DOI:10.1021/jm301756m

Reference yield:

tert-butyl ((2S,3R)-3-(tert-butoxy)-1-oxo-1-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzenesulfonamido)butan-2-yl)carbamate (1422970-00-0) + 7-bromo-quinazolin-4-ylamine (1123169-43-6) → C27H35N5O6S

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate; In water; at 140 ℃; Inert atmosphere; Microwave irradiation;

DOI:10.1021/jm301756m

Reference yield:

tert-butyl ((2S,3R)-3-(tert-butoxy)-1-oxo-1-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzenesulfonamido)butan-2-yl)carbamate (1422970-00-0) + 7-bromo-2,4-diaminoquinazoline (137553-43-6) → C27H36N6O6S

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate; In water; at 140 ℃; Inert atmosphere; Microwave irradiation;

DOI:10.1021/jm301756m

upstream raw materials:

3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzene-1-sulfonamide

(2S,3R)-3-tert-butoxy-2-tert-butoxycarbonylaminobutyric acid

Downstream raw materials:

C₁₈H₁₉N₅O₄S

C₁₈H₁₈ClN₅O₄S

C₁₉H₂₁N₅O₄S

C₁₉H₁₉ClN₄O₄S