3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-7-vinyl-4H-chromeno[4,3-c]isoxazole

Base Information

Chemical Name:3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-7-vinyl-4H-chromeno[4,3-c]isoxazole
CAS No.:1307813-61-1
Molecular Formula:C₂₂H₁₃F₃N₂O₃
Molecular Weight:410.352
Hs Code.:

Synonyms:3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-7-vinyl-4H-chromeno[4,3-c]isoxazole

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Chemical Property of 3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-7-vinyl-4H-chromeno[4,3-c]isoxazole

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Technology Process of 3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-7-vinyl-4H-chromeno[4,3-c]isoxazole

There total 12 articles about 3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-7-vinyl-4H-chromeno[4,3-c]isoxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 1307813-60-0
7-bromo-3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4Hchromeno[4,3-c]isoxazole

: 7486-35-3
tri-n-butyl(vinyl)tin

: 1307813-61-1
3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-7-vinyl-4H-chromeno[4,3-c]isoxazole

Guidance literature:: With lithium chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; at 100 ℃; Sealed tube; Inert atmosphere;

Reference yield:

: 1236188-87-6
5-phenyl-4-(trifluoromethyl)isoxazole-3-carboxylic acid

: 1307813-61-1
3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-7-vinyl-4H-chromeno[4,3-c]isoxazole

Guidance literature:: Multi-step reaction with 9 steps

1.1: 4-methyl-morpholine; isobutyl chloroformate / tetrahydrofuran / 0.33 h / 0 °C

1.2: 1 h / -78 °C

2.1: Dess-Martin periodane / dichloromethane / 1.17 h / 0 - 20 °C

3.1: triphenylphosphine / dichloromethane / 0.08 h / 0 °C

3.2: 0.33 h / 0 °C

4.1: n-butyllithium / hexane; tetrahydrofuran / 0.42 h / -78 °C

4.2: 0.08 h / 20 °C

5.1: phosphorus tribromide / dichloromethane / 0 - 20 °C

6.1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 20 °C

7.1: hydroxylamine hydrochloride; sodium acetate / methanol / 0.5 h / Reflux

8.1: triethylamine; sodium hypochlorite / dichloromethane / 2 h / 0 - 20 °C

9.1: lithium chloride / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 100 °C / Sealed tube; Inert atmosphere

With 4-methyl-morpholine; sodium hypochlorite; n-butyllithium; hydroxylamine hydrochloride; sodium acetate; phosphorus tribromide; potassium carbonate; Dess-Martin periodane; triethylamine; triphenylphosphine; lithium chloride; isobutyl chloroformate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; methanol; hexane; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1307812-27-6
5-phenyl-4-(trifluoromethyl)isoxazole-3-carbaldehyde

: 1307813-61-1
3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-7-vinyl-4H-chromeno[4,3-c]isoxazole

Guidance literature:: Multi-step reaction with 7 steps

1.1: triphenylphosphine / dichloromethane / 0.08 h / 0 °C

1.2: 0.33 h / 0 °C

2.1: n-butyllithium / hexane; tetrahydrofuran / 0.42 h / -78 °C

2.2: 0.08 h / 20 °C

3.1: phosphorus tribromide / dichloromethane / 0 - 20 °C

4.1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 20 °C

5.1: hydroxylamine hydrochloride; sodium acetate / methanol / 0.5 h / Reflux

6.1: triethylamine; sodium hypochlorite / dichloromethane / 2 h / 0 - 20 °C

7.1: lithium chloride / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 100 °C / Sealed tube; Inert atmosphere

With sodium hypochlorite; n-butyllithium; hydroxylamine hydrochloride; sodium acetate; phosphorus tribromide; potassium carbonate; triethylamine; triphenylphosphine; lithium chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; methanol; hexane; dichloromethane; N,N-dimethyl-formamide;