N-(2-fluoro-5-methoxycarbonyloxy-4-methylphenyl)-6-methoxy-7-methoxyacetamido-4-quinazolinylamine

Base Information

Chemical Name:N-(2-fluoro-5-methoxycarbonyloxy-4-methylphenyl)-6-methoxy-7-methoxyacetamido-4-quinazolinylamine
CAS No.:196195-05-8
Molecular Formula:C₂₁H₂₁FN₄O₆
Molecular Weight:444.419
Hs Code.:

Synonyms:N-(2-fluoro-5-methoxycarbonyloxy-4-methylphenyl)-6-methoxy-7-methoxyacetamido-4-quinazolinylamine

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Chemical Property of N-(2-fluoro-5-methoxycarbonyloxy-4-methylphenyl)-6-methoxy-7-methoxyacetamido-4-quinazolinylamine

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Technology Process of N-(2-fluoro-5-methoxycarbonyloxy-4-methylphenyl)-6-methoxy-7-methoxyacetamido-4-quinazolinylamine

There total 6 articles about N-(2-fluoro-5-methoxycarbonyloxy-4-methylphenyl)-6-methoxy-7-methoxyacetamido-4-quinazolinylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 38870-89-2
Methoxyacetyl chloride

: N-7-amino-(2-fluoro-5-methoxycarbonyloxy-4-methylphenyl)-6-methoxy-4-quinazolinylamine hydrochloride

: 196195-05-8
N-(2-fluoro-5-methoxycarbonyloxy-4-methylphenyl)-6-methoxy-7-methoxyacetamido-4-quinazolinylamine

Guidance literature:: In dichloromethane;

Reference yield:

: 196195-00-3
6-methoxy-7-nitro-3,4-dihydroquinazolin-4-one

: 196195-05-8
N-(2-fluoro-5-methoxycarbonyloxy-4-methylphenyl)-6-methoxy-7-methoxyacetamido-4-quinazolinylamine

Guidance literature:: Multi-step reaction with 4 steps

1: SOCl₂; DMF / Heating

2: propan-2-ol / 4 h / 80 °C

3: 91 percent / H₂ / 10 percent Pd/C / methanol; ethanol / 7 h / 2052 Torr

4: pyridine / 2 h / 20 °C

With pyridine; thionyl chloride; hydrogen; N,N-dimethyl-formamide; palladium on activated charcoal; In methanol; ethanol; isopropyl alcohol; 1: Chlorination / 2: Substitution / 3: Reduction / 4: Acylation;
DOI:10.1021/jm990345w

Reference yield:

: 196194-99-7
2-amino-5-methoxy-4-nitrobenzoic acid

: 196195-05-8
N-(2-fluoro-5-methoxycarbonyloxy-4-methylphenyl)-6-methoxy-7-methoxyacetamido-4-quinazolinylamine

Guidance literature:: Multi-step reaction with 5 steps

1: 67 percent / 4.5 h / Heating

2: SOCl₂; DMF / Heating

3: propan-2-ol / 4 h / 80 °C

4: 91 percent / H₂ / 10 percent Pd/C / methanol; ethanol / 7 h / 2052 Torr

5: pyridine / 2 h / 20 °C

With pyridine; thionyl chloride; hydrogen; N,N-dimethyl-formamide; palladium on activated charcoal; In methanol; ethanol; isopropyl alcohol; 1: Formylation; Cyclization / 2: Chlorination / 3: Substitution / 4: Reduction / 5: Acylation;
DOI:10.1021/jm990345w