(S)-tert-butyl 2-(((S)-1-(((S)-1-((S)-2-(ethoxycarbonyl)pyrrolidin-1-yl)-1-oxo-3-phenylpropan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)carbamoyl)pyrrolidine-1-carboxylate

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Chemical Name:(S)-tert-butyl 2-(((S)-1-(((S)-1-((S)-2-(ethoxycarbonyl)pyrrolidin-1-yl)-1-oxo-3-phenylpropan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)carbamoyl)pyrrolidine-1-carboxylate
CAS No.:1427166-51-5
Molecular Formula:C₃₂H₄₈N₄O₇
Molecular Weight:600.756
Hs Code.:

(S)-tert-butyl 2-(((S)-1-(((S)-1-((S)-2-(ethoxycarbonyl)pyrrolidin-1-yl)-1-oxo-3-phenylpropan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)carbamoyl)pyrrolidine-1-carboxylate

Synonyms:(S)-tert-butyl 2-(((S)-1-(((S)-1-((S)-2-(ethoxycarbonyl)pyrrolidin-1-yl)-1-oxo-3-phenylpropan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)carbamoyl)pyrrolidine-1-carboxylate

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Chemical Property of (S)-tert-butyl 2-(((S)-1-(((S)-1-((S)-2-(ethoxycarbonyl)pyrrolidin-1-yl)-1-oxo-3-phenylpropan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)carbamoyl)pyrrolidine-1-carboxylate

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Technology Process of (S)-tert-butyl 2-(((S)-1-(((S)-1-((S)-2-(ethoxycarbonyl)pyrrolidin-1-yl)-1-oxo-3-phenylpropan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)carbamoyl)pyrrolidine-1-carboxylate

There total 6 articles about (S)-tert-butyl 2-(((S)-1-(((S)-1-((S)-2-(ethoxycarbonyl)pyrrolidin-1-yl)-1-oxo-3-phenylpropan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)carbamoyl)pyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 68385-28-4
(2S)-2-{[(2S)-1-(tert-butoxycarbonyl)pyrrolidine-2-carbonyl]amino}-4-methylpentanoic acid

: 99295-22-4
(S)-1-((S)-2-(ethoxycarbonyl)pyrrolidin-1-yl)-1-oxo-3-phenylpropan-2-aminium chloride

: 1427166-51-5
(S)-tert-butyl 2-(((S)-1-(((S)-1-((S)-2-(ethoxycarbonyl)pyrrolidin-1-yl)-1-oxo-3-phenylpropan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)carbamoyl)pyrrolidine-1-carboxylate

Guidance literature:: With 4-methyl-morpholine; isobutyl chloroformate; In tetrahydrofuran; N,N-dimethyl-formamide; at -15 - 25 ℃; for 12h; Inert atmosphere;
DOI:10.1039/c3cc39291k

Reference yield:

: 1427166-47-9
(S)-ethyl 1-((S)-2-((tert-butoxycarbonyl)amino)-3-phenylpropanoyl)pyrrolidine-2-carboxylate

: 1427166-51-5
(S)-tert-butyl 2-(((S)-1-(((S)-1-((S)-2-(ethoxycarbonyl)pyrrolidin-1-yl)-1-oxo-3-phenylpropan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)carbamoyl)pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / 1,4-dioxane / 1 h / 25 °C

2: 4-methyl-morpholine; isobutyl chloroformate / N,N-dimethyl-formamide; tetrahydrofuran / 12 h / -15 - 25 °C / Inert atmosphere

With 4-methyl-morpholine; hydrogenchloride; isobutyl chloroformate; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide;
DOI:10.1039/c3cc39291k

Reference yield:

: 13734-34-4
N-tert-butoxycarbonyl-L-phenylalanine

: 1427166-51-5
(S)-tert-butyl 2-(((S)-1-(((S)-1-((S)-2-(ethoxycarbonyl)pyrrolidin-1-yl)-1-oxo-3-phenylpropan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)carbamoyl)pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: dicyclohexyl-carbodiimide / dichloromethane / 0.5 h / Inert atmosphere

1.2: 12 h / 25 °C / Inert atmosphere

2.1: triethylamine / acetonitrile; water / 16 h / -40 - 25 °C

3.1: hydrogenchloride / 1,4-dioxane / 1 h / 25 °C

4.1: 4-methyl-morpholine; isobutyl chloroformate / N,N-dimethyl-formamide; tetrahydrofuran / 12 h / -15 - 25 °C / Inert atmosphere

With 4-methyl-morpholine; hydrogenchloride; triethylamine; dicyclohexyl-carbodiimide; isobutyl chloroformate; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1039/c3cc39291k