3-BROMO-2-N-BOC-AMINO-PROPIONIC ACID METHYL ESTER

Base Information

• Chemical Name: 3-BROMO-2-N-BOC-AMINO-PROPIONIC ACID METHYL ESTER
• CAS No.: 1219200-16-4
• Molecular Formula: C₉H₁₆BrNO₄
• Molecular Weight: 282.134
• Mol file: 1219200-16-4.mol

Synonyms:methyl 3-bromo-2-[(tert-butoxycarbonyl)-amino]propanoate

Chemical Property of 3-BROMO-2-N-BOC-AMINO-PROPIONIC ACID METHYL ESTER

Chemical Property:

• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

3-Bromo-2-N-boc-amino-propionicAcidMethylEster ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: (R)?-?Methyl 3-?Bromo-?2-?((tert-?butoxycarbonyl)?amino)?propanoate is a chiral reagent used in organic synthesis. Used in the synthesis of selenocysteine-containing peptides.

Technology Process of 3-BROMO-2-N-BOC-AMINO-PROPIONIC ACID METHYL ESTER

There total 1 articles about 3-BROMO-2-N-BOC-AMINO-PROPIONIC ACID METHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-tert-butoxycarbonylserine methyl ester (69942-12-7) → methyl 3-bromo-2-[(tert-butoxycarbonyl)-amino]propanoate (1219200-16-4,402726-50-5)

Guidance literature:

With carbon tetrabromide; triphenylphosphine; In dichloromethane; at 0 - 25 ℃; for 3h;

Reference yield: 51.0%

methyl 3-bromo-2-[(tert-butoxycarbonyl)-amino]propanoate (1219200-16-4,402726-50-5) + 4-methoxyphenylboronic acid (5720-07-0) → methyl N-(tert-butoxycarbonyl)-3-[(4-methoxyphenyl)sulfonyl]alaninate

Guidance literature:

With dichloro bis(acetonitrile) palladium(II); potassium pyrosulfite; tetrabutylammomium bromide; tert-butyl XPhos; In N,N-dimethyl-formamide; at 85 ℃; for 22h; Inert atmosphere; Sealed tube;

DOI:10.1002/anie.201505918

upstream raw materials:

N-tert-butoxycarbonylserine methyl ester

Refernces