(5R,8R)-12-(benzoyloxy)-5,8-bis<(tert-butyldimethylsilyl)oxy>-1-dodecanol

Base Information

Chemical Name:(5R,8R)-12-(benzoyloxy)-5,8-bis<(tert-butyldimethylsilyl)oxy>-1-dodecanol
CAS No.:142841-62-1
Molecular Formula:C₃₁H₅₈O₅Si₂
Molecular Weight:566.97
Hs Code.:

Synonyms:(5R,8R)-12-(benzoyloxy)-5,8-bis<(tert-butyldimethylsilyl)oxy>-1-dodecanol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (5R,8R)-12-(benzoyloxy)-5,8-bis<(tert-butyldimethylsilyl)oxy>-1-dodecanol

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Technology Process of (5R,8R)-12-(benzoyloxy)-5,8-bis<(tert-butyldimethylsilyl)oxy>-1-dodecanol

There total 4 articles about (5R,8R)-12-(benzoyloxy)-5,8-bis<(tert-butyldimethylsilyl)oxy>-1-dodecanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

: 142841-63-2
(5R,8R)-1,12-bis(benzoyloxy)-5,8-bis<(tert-butyldimethylsilyl)oxy>-1-dodecanol

: 142841-62-1
(5R,8R)-12-(benzoyloxy)-5,8-bis<(tert-butyldimethylsilyl)oxy>-1-dodecanol

Guidance literature:: With sodium hydroxide; In tetrahydrofuran; methanol; at 0 ℃; for 1.5h;
DOI:10.1021/jo00045a034

Reference yield: 41.0%

: 131618-30-9
(5R,8R)-5,8-Bis<(tert-butyldimethylsilyl)oxy>-1,12-dodecanediol

: 98-88-4
benzoyl chloride

: 142841-62-1
(5R,8R)-12-(benzoyloxy)-5,8-bis<(tert-butyldimethylsilyl)oxy>-1-dodecanol

: 142841-63-2
(5R,8R)-1,12-bis(benzoyloxy)-5,8-bis<(tert-butyldimethylsilyl)oxy>-1-dodecanol

Guidance literature:: With dmap; In dichloromethane; for 1.5h; Ambient temperature;
DOI:10.1021/jo00045a034

Reference yield:

: 131618-30-9
(5R,8R)-5,8-Bis<(tert-butyldimethylsilyl)oxy>-1,12-dodecanediol

: 142841-62-1
(5R,8R)-12-(benzoyloxy)-5,8-bis<(tert-butyldimethylsilyl)oxy>-1-dodecanol

Guidance literature:: Multi-step reaction with 2 steps

1: 41 percent / 4-(dimethylamino)pyridine / CH₂Cl₂ / 1.5 h / Ambient temperature

2: 44 percent / 10percent aq. NaOH / tetrahydrofuran; methanol / 1.5 h / 0 °C

With dmap; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/jo00045a034