1-{2-[N-(α,α-dimethylbenzyl)-N-but-3-enylcarbamoyl]-4-methylphenyl}-4-[2-(N-(1-ethylcyclopentyl)-N-{2-[(tert-butyldiphenylsilyl)oxy]ethyl}carbamoyl)phenyl]-2-butanol

Base Information

Chemical Name:1-{2-[N-(α,α-dimethylbenzyl)-N-but-3-enylcarbamoyl]-4-methylphenyl}-4-[2-(N-(1-ethylcyclopentyl)-N-{2-[(tert-butyldiphenylsilyl)oxy]ethyl}carbamoyl)phenyl]-2-butanol
CAS No.:179096-57-2
Molecular Formula:C₅₇H₇₂N₂O₄Si
Molecular Weight:877.295
Hs Code.:

1-{2-[N-(α,α-dimethylbenzyl)-N-but-3-enylcarbamoyl]-4-methylphenyl}-4-[2-(N-(1-ethylcyclopentyl)-N-{2-[(tert-butyldiphenylsilyl)oxy]ethyl}carbamoyl)phenyl]-2-butanol

Synonyms:1-{2-[N-(α,α-dimethylbenzyl)-N-but-3-enylcarbamoyl]-4-methylphenyl}-4-[2-(N-(1-ethylcyclopentyl)-N-{2-[(tert-butyldiphenylsilyl)oxy]ethyl}carbamoyl)phenyl]-2-butanol

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Chemical Property of 1-{2-[N-(α,α-dimethylbenzyl)-N-but-3-enylcarbamoyl]-4-methylphenyl}-4-[2-(N-(1-ethylcyclopentyl)-N-{2-[(tert-butyldiphenylsilyl)oxy]ethyl}carbamoyl)phenyl]-2-butanol

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Technology Process of 1-{2-[N-(α,α-dimethylbenzyl)-N-but-3-enylcarbamoyl]-4-methylphenyl}-4-[2-(N-(1-ethylcyclopentyl)-N-{2-[(tert-butyldiphenylsilyl)oxy]ethyl}carbamoyl)phenyl]-2-butanol

There total 13 articles about 1-{2-[N-(α,α-dimethylbenzyl)-N-but-3-enylcarbamoyl]-4-methylphenyl}-4-[2-(N-(1-ethylcyclopentyl)-N-{2-[(tert-butyldiphenylsilyl)oxy]ethyl}carbamoyl)phenyl]-2-butanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: N-But-3-enyl-2-(4-{2-[[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-(1-ethyl-cyclopentyl)-carbamoyl]-phenyl}-2-oxo-butyl)-5-methyl-N-(1-methyl-1-phenyl-ethyl)-benzamide

: 179096-57-2
1-{2-[N-(α,α-dimethylbenzyl)-N-but-3-enylcarbamoyl]-4-methylphenyl}-4-[2-(N-(1-ethylcyclopentyl)-N-{2-[(tert-butyldiphenylsilyl)oxy]ethyl}carbamoyl)phenyl]-2-butanol

Guidance literature:: With sodium tetrahydroborate; In ethanol; Ambient temperature;
DOI:10.1021/jm960092w

Reference yield:

: 67404-87-9
1-ethylcyclopentan-1-amine

: 179096-57-2
1-{2-[N-(α,α-dimethylbenzyl)-N-but-3-enylcarbamoyl]-4-methylphenyl}-4-[2-(N-(1-ethylcyclopentyl)-N-{2-[(tert-butyldiphenylsilyl)oxy]ethyl}carbamoyl)phenyl]-2-butanol

Guidance literature:: Multi-step reaction with 8 steps

1: 1.) LiClO₄ / 1.) THF, 0 deg C, 10 min, 2.) THF, CH₃CN, RT, 3 h

2: imidazole / CH₂Cl₂ / 18 h / Ambient temperature

3: Et₃N / CH₂Cl₂ / 21 h / Ambient temperature

4: 1.) diisopropylamine, sec-butyllithium / 1.) THF, -70 deg C, 1.5 h, 2.) THF, RT, 16 h

5: Jone's reagent / acetone

6: DEPC, diisopropylethylamine / CH₂Cl₂ / 2 h / Ambient temperature

7: 1.) diisopropylamine, sec-butyllithium / 1.) THF, cyclohexane, -78 deg C, 35 min, 2.) THF, cyclohexane, from -78 deg C to RT, 1 h

8: 99 percent / NaBH₄ / ethanol / Ambient temperature

With 1H-imidazole; sodium tetrahydroborate; Jones reagent; sec.-butyllithium; lithium perchlorate; triethylamine; diisopropylamine; N-ethyl-N,N-diisopropylamine; diethyl dicarbonate; In ethanol; dichloromethane; acetone;
DOI:10.1021/jm960092w

Reference yield:

: 22328-43-4
2,5-dimethylbenzoyl chloride

: 179096-57-2
1-{2-[N-(α,α-dimethylbenzyl)-N-but-3-enylcarbamoyl]-4-methylphenyl}-4-[2-(N-(1-ethylcyclopentyl)-N-{2-[(tert-butyldiphenylsilyl)oxy]ethyl}carbamoyl)phenyl]-2-butanol

Guidance literature:: Multi-step reaction with 3 steps

1: 59 percent / Et₃N / CH₂Cl₂ / 5 h / Ambient temperature

2: 1.) diisopropylamine, sec-butyllithium / 1.) THF, cyclohexane, -78 deg C, 35 min, 2.) THF, cyclohexane, from -78 deg C to RT, 1 h

3: 99 percent / NaBH₄ / ethanol / Ambient temperature

With sodium tetrahydroborate; sec.-butyllithium; triethylamine; diisopropylamine; In ethanol; dichloromethane;
DOI:10.1021/jm960092w